新利18网址|新利官方网站

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\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n

\u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u5df4\u585e\u5c14\u5927\u5b66\u7684\u535a\u58eb\u751f\u9648\u680b\u840d\u4e3a\u6211\u4eec\u5206\u4eab\u3002<\/p>\n

2024\u5e747\u670819\u65e5\uff0cNature Chemistry<\/em>\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u745e\u58eb\u5df4\u585e\u5c14\u5927\u5b66\u7684Thomas R. Ward\u6559\u6388\u8bfe\u9898\u7ec4\u9898\u4e3a\u300cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u57fa\u4e8e\u751f\u7269\u7d20\u548c\u94fe\u9709\u4eb2\u548c\u7d20\u7684\u5f3a\u4eb2\u548c\u529b\uff0c\u4f5c\u8005\u901a\u8fc7\u5728\u5de5\u7a0b\u5316\u6539\u9020\u7684\u5d4c\u5408\u94fe\u9709\u4eb2\u548c\u7d20\u4e2d\u951a\u5b9a\u751f\u7269\u7d20[Co(schiff-base)] \u7684\u4eba\u9020\u8f85\u56e0\u5b50\u800c\u6784\u5efa\u4e86\u4eba\u5de5\u81ea\u7531\u57fa\u73af\u5316\u9176\uff08ARCase\uff09\u3002\u7ecf\u8fc7\u8ba1\u7b97\u8f85\u52a9\u7684\u86cb\u767d\u6539\u9020\u4ee5\u53ca\u4e24\u8f6e\u5b9a\u5411\u8fdb\u5316\u83b7\u5f97\u7684\u6700\u4f73\u7a81\u53d8\u4f53\u53ef\u4ee5\u987a\u5229\u5730\u50ac\u5316\u81ea\u7531\u57fa\u73af\u5316\u53cd\u5e94\uff0c\u4e00\u6b65\u5408\u6210\u5177\u6709cis<\/em>-5-6-\u7a20\u73af\u7ed3\u6784\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u7684\u53cc\u73af\u4ea7\u7269\u3002QM\/MM\u8ba1\u7b97\u4ee5\u53ca\u5355\u6676\u7ed3\u6784\u8bc1\u660e\u7a81\u53d8\u5f15\u5165\u7684\u7ec4\u6c28\u9178\u6b8b\u57fa\u4e0e\u50ac\u5316\u4e2d\u5fc3\u7684\u94b4\u539f\u5b50\u5177\u6709\u914d\u4f4d\u4f5c\u7528\u3002\u901a\u8fc7\u5bf9\u53cd\u5e94\u8fc7\u7a0b\u7684\u5b9e\u65f6\u76d1\u6d4b\uff0c\u63ed\u9732\u4e86ARCase \u6210\u529f\u5730\u50ac\u5316\u4e86\u4e00\u4e2a\u5305\u542b\u4e24\u6b65\u53cd\u5e94\u7684\u7ea7\u8054\u8fc7\u7a0b\uff0c\u5373\u94b4\u6c22\u4ecb\u5bfc\u7684\u81ea\u7531\u57fa\u73af\u5316\u548c\u5171\u8f6d\u8fd8\u539f\u53cd\u5e94\u3002\u6b64\u5916\uff0cARCase\u5bf9\u4e8c\u70ef\u916e\u5e95\u7269\u7684\u53d8\u5316\u8868\u73b0\u51fa\u8f83\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u7ed3\u5408\u5316\u5b66\u5408\u6210\u4e0e\u9176\u5408\u6210\u7b56\u7565\uff0c\u53ef\u4ee5\u5feb\u901f\u5b9e\u73b0\u841c\u7c7b\u5316\u5408\u7269\u4e2d\u7684\u4e09\u73af\u9aa8\u67b6\u7684\u624b\u6027\u6784\u5efa\uff0c \u5c55\u793a\u4e86\u5176\u5728\u590d\u6742\u841c\u7c7b\u5316\u5408\u7269\u751a\u81f3\u836f\u7269\u5206\u5b50\u5408\u6210\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n

\n
\u201cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway.<\/p>\n
Dongping Chen\u2021, Xiang Zhang\u2021 Anastassia Andreevna Vorobieva, Ryo Tachibana, Alina Stein, Roman P. Jakob, Zhi Zou, Damian Alexander Graf, Ang Li, Timm Maier, Bruno E. Correia*, Thomas R. Ward*<\/p>\n
Nat.Chem.<\/em>\u00a02024<\/strong>. Doi:10.1038\/s41557-024-01562-5\u201d<\/a><\/p>\n<\/blockquote>\n
<\/p>\n
Q1. <\/strong>\u8bf7\u5bf9<\/strong>\u201cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway\u201d<\/strong>\u4f5c<\/strong>\u4e00\u4e2a\u7b80\u5355\u4ecb\u7ecd\u3002<\/strong><\/h4>\n
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Q3.<\/strong>\u672c\u6b21\u7814\u7a76\u4e3b\u4f53\uff0c\u6709\u6ca1\u6709\u4ec0\u4e48\u8ba9\u60a8\u611f\u89c9\u7279\u522b\u8f9b\u82e6\u548c\u70e7\u8111\u5462\uff1f<\/strong><\/h4>\n
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Q4. <\/strong>\u5c06\u6765\u60f3\u7ee7\u7eed\u7814\u7a76\u5316\u5b66\u7684\u54ea\u4e2a\u65b9\u5411\u5462\uff1f<\/strong><\/h4>\n
\u76ee\u524d\uff0c\u535a\u58eb\u5373\u5c06\u6bd5\u4e1a\u3002\u5e0c\u671b\u4ee5\u540e\u80fd\u591f\u4ece\u4e8b\u4eba\u5de5\u91d1\u5c5e\u9176\uff0c\u86cb\u767d\u8bbe\u8ba1\uff0c\u5408\u6210\u751f\u7269\u5b66\u7684\u76f8\u5173\u5de5\u4f5c\u3002<\/p>\n
Q5. <\/strong>\u6700\u540e\uff0c\u6709\u4ec0\u4e48\u60f3\u5bf9\u5404\u4f4d\u8bfb\u8005\u8bf4\u7684\u5417\uff1f<\/strong><\/h4>\n
\u79d1\u5b66\u7814\u7a76\u662f\u4e00\u4e2a\u9700\u8981\u4e0d\u65ad\u8bd5\u9519\u3001\u4e0d\u65ad\u63a2\u7d22\u7684\u65c5\u9014\uff0c\u5927\u90e8\u5206\u65f6\u95f4\u5e76\u4e0d\u4e00\u5b9a\u80fd\u591f\u5982\u5df1\u6240\u613f\uff0c\u4f46\u8d35\u5728\u575a\u6301\uff0c\u6211\u4eec\u53ef\u4ee5\u4ece\u8fd9\u4e2a\u65c5\u9014\u4e2d\u5f97\u5230\u591a\u4e2a\u7ef4\u5ea6\u7684\u8bad\u7ec3\uff0c\u800c\u8fd9\u4e9b\u7ecf\u9a8c\u6559\u8bad\u5bf9\u4ee5\u540e\u7684\u7814\u7a76\u5de5\u4f5c\u6765\u8bf4\u662f\u4e00\u4e2a\u5b9d\u8d35\u7684\u8d22\u5bcc\u3002\u6211\u5f88\u611f\u6fc0\u5728\u8fd9\u4e2a\u9879\u76ee\u7684\u63a2\u7d22\u8fc7\u7a0b\u4e2d\uff0c\u6211\u7684\u5bfc\u5e08Prof. Thomas R. Ward\u5bf9\u6211\u7684\u8010\u5fc3\u6307\u5bfc\uff0c\u65e0\u6761\u4ef6\u5730\u652f\u6301\u548c\u6781\u5927\u7684\u9f13\u52b1\uff0c\u4fc3\u4f7f\u6211\u5feb\u901f\u6210\u957f\u5e76\u79ef\u6781\u63a8\u52a8\u8bfe\u9898\u524d\u8fdb\u3002\u5f88\u611f\u6fc0\u6211\u4eec\u56e2\u961f\u91cc\u7684\u6bcf\u4e00\u4e2a\u6210\u5458\u7684\u52aa\u529b\uff0c\u4ed6\u4eec\u4e5f\u4e3a\u8fd9\u4efd\u5de5\u4f5c\u7684\u53d1\u8868\u505a\u51fa\u4e86\u5de8\u5927\u8d21\u732e\u3002\u8fd9\u4efd\u5de5\u4f5c\u5c06\u4f1a\u6210\u4e3a\u6211\u7684\u4e2a\u4eba\u6210\u957f\u548c\u804c\u4e1a\u53d1\u5c55\u4e2d\u975e\u5e38\u91cd\u8981\u7684\u7ecf\u5386\u3002<\/p>\n
\u4f5c\u8005\u6559\u80b2\u80cc\u666f\u7b80\u4ecb<\/strong><\/h4>\n
<\/strong><\/p>\n
\u6559\u80b2\u80cc\u666f\uff1a<\/strong><\/h4>\n
2020.08-\u73b0\u5728\uff0c\u535a\u58eb\u5728\u8bfb\uff0c\u5df4\u585e\u5c14\u5927\u5b66\uff0c Prof. Thomas R Ward<\/p>\n
2014.09-2017.07\uff0c \u7855\u58eb\uff0c\u4e0a\u6d77\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\uff0c \u6c64\u6587\u519b\u7814\u7a76\u5458<\/p>\n
2010.09-2014.06\uff0c\u5b66\u58eb\uff0c\u5357\u4eac\u5de5\u4e1a\u5927\u5b66<\/p>\n
\u83b7\u5956\u7ecf\u5386\uff1a<\/strong><\/h4>\n
2024\uff0c Swiss Chemistry Travel Award<\/p>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u5df4\u585e\u5c14\u5927\u5b66\u7684\u535a\u58eb\u751f\u9648\u680b\u840d\u4e3a\u6211\u4eec\u5206\u4eab\u3002 2024\u5e747\u670819\u65e5\uff0c Nature Chemistry\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u745e\u58eb\u5df4\u585e\u5c14\u5927\u5b66\u7684Thomas R. Ward\u6559\u6388\u8bfe\u9898\u7ec4\u9898\u4e3a\u300cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u57fa\u4e8e\u751f\u7269\u7d20\u548c\u94fe\u9709\u4eb2\u548c\u7d20\u7684\u5f3a\u4eb2\u548c\u529b\uff0c\u4f5c\u8005\u901a\u8fc7\u5728\u5de5\u7a0b\u5316\u6539\u9020\u7684\u5d4c\u5408\u94fe\u9709\u4eb2\u548c\u7d20\u4e2d\u951a\u5b9a\u751f\u7269\u7d20[Co(schiff-base)] \u7684\u4eba\u9020\u8f85\u56e0\u5b50\u800c\u6784\u5efa\u4e86\u4eba\u5de5\u81ea\u7531\u57fa\u73af\u5316\u9176\uff08ARCase\uff09\u3002\u7ecf\u8fc7\u8ba1\u7b97\u8f85\u52a9\u7684\u86cb\u767d\u6539\u9020\u4ee5\u53ca\u4e24\u8f6e\u5b9a\u5411\u8fdb\u5316\u83b7\u5f97\u7684\u6700\u4f73\u7a81\u53d8\u4f53\u53ef\u4ee5\u987a\u5229\u5730\u50ac\u5316\u81ea\u7531\u57fa\u73af\u5316\u53cd\u5e94\uff0c\u4e00\u6b65\u5408\u6210\u5177\u6709cis-5-6-\u7a20\u73af\u7ed3\u6784\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u7684\u53cc\u73af\u4ea7\u7269\u3002QM\/MM\u8ba1\u7b97\u4ee5\u53ca\u5355\u6676\u7ed3\u6784\u8bc1\u660e\u7a81\u53d8\u5f15\u5165\u7684\u7ec4\u6c28\u9178\u6b8b\u57fa\u4e0e\u50ac\u5316\u4e2d\u5fc3\u7684\u94b4\u539f\u5b50\u5177\u6709\u914d\u4f4d\u4f5c\u7528\u3002\u901a\u8fc7\u5bf9\u53cd\u5e94\u8fc7\u7a0b\u7684\u5b9e\u65f6\u76d1\u6d4b\uff0c\u63ed\u9732\u4e86ARCase \u6210\u529f\u5730\u50ac\u5316\u4e86\u4e00\u4e2a\u5305\u542b\u4e24\u6b65\u53cd\u5e94\u7684\u7ea7\u8054\u8fc7\u7a0b\uff0c\u5373\u94b4\u6c22\u4ecb\u5bfc\u7684\u81ea\u7531\u57fa\u73af\u5316\u548c\u5171\u8f6d\u8fd8\u539f\u53cd\u5e94\u3002\u6b64\u5916\uff0cARCase\u5bf9\u4e8c\u70ef\u916e\u5e95\u7269\u7684\u53d8\u5316\u8868\u73b0\u51fa\u8f83\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u7ed3\u5408\u5316\u5b66\u5408\u6210\u4e0e\u9176\u5408\u6210\u7b56\u7565\uff0c\u53ef\u4ee5\u5feb\u901f\u5b9e\u73b0\u841c\u7c7b\u5316\u5408\u7269\u4e2d\u7684\u4e09\u73af\u9aa8\u67b6\u7684\u624b\u6027\u6784\u5efa\uff0c \u5c55\u793a\u4e86\u5176\u5728\u590d\u6742\u841c\u7c7b\u5316\u5408\u7269\u751a\u81f3\u836f\u7269\u5206\u5b50\u5408\u6210\u4e2d\u7684\u6f5c\u529b\u3002 \u201cAn Evolved Artificial Radical Cyclase Enables the Construction of Bicyclic Terpenoid Scaffolds via an H-Atom Transfer Pathway. Dongping Chen\u2021, Xiang Zhang\u2021 Anastassia Andreevna Vorobieva, Ryo Tachibana, Alina Stein, Roman P. Jakob, Zhi Zou, Damian Alexander Graf, Ang Li, Timm Maier, Bruno E. Correia*, Thomas R. Ward* Nat.Chem.\u00a02024. 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\u672c\u6587\u4f5c\u8005\uff1aAzathoth <\/strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u5199\u4f5c\u6307\u5bfc\uff1aCyclization Xu<\/strong><\/p>\n
\u5bfc\u8bfb<\/strong>\uff1a<\/h4>\n
\u672c\u6587\u4ecb\u7ecd\u4e86\u9530\u50ac\u5316\u6c22\u5316\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u6587\u4e2d\u63cf\u8ff0\u4e86\u4e0d\u540c\u7c7b\u578b\u9530\u50ac\u5316\u5242\u7684\u8bbe\u8ba1\u4e0e\u6027\u80fd\uff0c\u901a\u8fc7\u5206\u6790\u4e0d\u540c\u914d\u4f53\u548c\u53cd\u5e94\u6761\u4ef6\u5bf9\u50ac\u5316\u6548\u7387\u548c\u9009\u62e9\u6027\u7684\u5f71\u54cd\uff0c\u5c55\u793a\u4e86\u9530\u50ac\u5316\u5242\u5728\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u4e2d\u7684\u6f5c\u529b\u3002\u6e05\u534e\u5927\u5b66\u5218\u5f3a\u56e2\u961f\u63d0\u51fa\u4e86\u5173\u4e8e\u9530\u50ac\u5316\u6c22\u5316\u7684\u591a\u79cd\u6d3b\u5316\u6a21\u578b\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u5728\u50ac\u5316\u5242\u7684\u8bbe\u8ba1\u4e0a\uff0c\u63a8\u52a8\u4e86\u8be5\u9886\u57df\u7684\u5feb\u901f\u53d1\u5c55\u3002<\/p>\n
\u6b63\u6587<\/strong>\uff1a<\/h4>\n
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Fig.1.<\/strong> Typical outer-sphere mechanism catalytic hydrogenation<\/p>\n
\u76ee\u524d\u516c\u8ba4\u6700\u65e9\u7684\u5747\u76f8\u9530\u50ac\u5316\u6c22\u5316\u662f\u7531Beller \u7b49\u4eba\u5b9e\u73b0\u7684^{[1]<\/sup>\uff0c\u4ed6\u4eec\u7528PNP\u4e09\u9f7f\u914d\u4f53\u548c\u9530\u7684\u7edc\u5408\u7269\u5b9e\u73b0\u4e86\u82ef\u8148\u3001\u919b\u3001\u916e\u7684\u6c22\u5316\u3002Beller\u7684\u7814\u7a76\u8868\u660e\uff0c\u9530\u50ac\u5316\u5242\u5fc5\u987b\u8981\u6709\u4e00\u6c27\u5316\u78b3\u914d\u4f4d\uff0c\u901a\u8fc7\u53cd\u4f4d\u6548\u5e94\u6765\u7a33\u5b9a\u9530-\u6c22\u952e\uff0c\u5426\u5219\u9530\u6c22\u7269\u79cd\u7684\u80fd\u91cf\u4f1a\u975e\u5e38\u9ad8\uff0c\u96be\u4ee5\u751f\u6210\uff0c\u4ece\u800c\u65e0\u6cd5\u5b9e\u73b0\u50ac\u5316\u6c22\u5316\u3002<\/p>\n}
Scheme 1. <\/strong>One of the earliest homogeneous manganese-catalyzed hydrogenation reactions: hydrogenation of nitriles.Fig.2. <\/strong>Mechanism of manganese-catalyzed hydrogenation<\/p>\n
\u5f71\u54cd\u53cd\u5e94\u6d3b\u6027\u65e0\u5916\u4e4e\u4e24\u4e2a\u4e3b\u8981\u539f\u56e0\uff1a\u7a7a\u95f4\u4f4d\u963b\u548c\u7535\u5b50\u6548\u5e94\u3002\u5bf9\u4e8e\u5747\u76f8\u7684\u9530\u50ac\u5316\u6c22\u5316\u53cd\u5e94\u800c\u8a00\uff0c\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u66f4\u5bcc\u7535\u5b50\u3001\u66f4\u5c0f\u4f4d\u963b\u7684\u50ac\u5316\u5242\u62e5\u6709\u76f8\u5bf9\u66f4\u9ad8\u7684\u6d3b\u6027\u3002\u5c0f\u7684\u4f4d\u963b\u6709\u5229\u4e8e\u50ac\u5316\u5242\u4e0e\u5e95\u7269\u63a5\u8fd1\uff0c\u800c\u5bcc\u7535\u5b50\u6709\u5229\u4e8e\u63d0\u9ad8\u91d1\u5c5e\u6c22\u7269\u79cd\u7684\u4eb2\u6838\u80fd\u529b\u3002\u5982Kempt\u7684\u5de5\u4f5c\u6240\u793a\uff0c\u5f53\u5421\u5576\u914d\u4f4d\u57fa\u56e2\u7684\u5bf9\u4f4d\u6709\u6c28\u57fa\u53d6\u4ee3\u65f6\uff0c\u50ac\u5316\u5242\u7684\u6d3b\u6027\u4f1a\u5f97\u5230\u63d0\u5347^{[2]<\/sup>\u3002Beller\u540e\u7eed\u7684\u5de5\u4f5c\u4e5f\u663e\u793a\u4e86\u4f4d\u963b\u5bf9\u50ac\u5316\u5242\u6d3b\u6027\u7684\u5f71\u54cd^{[3]<\/sup>\u3002Scheme 2. <\/strong>The enhancement of the electron-donating ability of the ligand is beneficial for improving catalytic activity.<\/p>\n}}
Scheme 3. <\/strong>The reduction of ligand steric hindrance is beneficial for improving catalytic activity.<\/p>\n
Beller \u3001Clarke\u3001Rueping\u3001Balskus\u7b49\u4eba\u5206\u522b\u4ee5\u54aa\u5511\u3001\u5421\u5576\u4e3a\u914d\u4f4d\u57fa\u56e2\u8bbe\u8ba1\u4e86PNN\u914d\u4f53^{[4] [5] [6]<\/sup>\uff0cPNN-Mn\u7684\u50ac\u5316\u6d3b\u6027\u76f8\u5bf9\u4e8ePNP-Mn\u50ac\u5316\u5242\u6709\u5de8\u5927\u7684\u63d0\u5347\u3002PNN-Mn\u50ac\u5316\u5242\u53ef\u4ee5\u6c22\u5316\u5982\u9170\u80fa\u3001\u916f\u548c\u78b3\u9178\u916f\u8fd9\u4e9b\u5177\u6709\u5f88\u5927\u6311\u6218\u6027\u7684\u5e95\u7269\uff0c\u8fd9\u662f\u5f88\u591aPNP-Mn\u50ac\u5316\u5242\u96be\u4ee5\u5b9e\u73b0\u7684\u3002<\/p>\n}
Scheme 4. <\/strong>In most cases, PNN ligands exhibit higher reaction activity than PNP ligands.<\/p>\n
\u540e\u6765\u6e05\u534e\u5927\u5b66\u5218\u5f3a\u548c\u91cd\u5e86\u5927\u5b66\u84dd\u5b87\u89e3\u91ca\u4e86PNN-Mn\u7edc\u5408\u7269\u6d3b\u6027\u5f3a\u4e8ePNP-Mn\u7edc\u5408\u7269\u7684\u539f\u56e0\uff1a\u4ed6\u4eec\u8ba4\u4e3aPNN\u914d\u4f53\u76f8\u5bf9\u4e8ePNP\u914d\u4f53\u7684\u4f18\u52bf\u5728\u4e8e\u4f4d\u963b\u5c0f\u3001\u5bcc\u7535\u5b50\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u6c22\u5316\u53cd\u5e94\u7684\u80fd\u5792^{[7]<\/sup>\u3002<\/p>\n}
Fig.3. <\/strong>Reasons for higher activity of PNN ligands: reduced steric hindrance, electron-rich nature, lowering the energy of substrate-catalyst adducts, facilitating easier reactions.<\/p>\n
\u968f\u7740\u4ee5\u4e0a\u7814\u7a76\u7684\u6df1\u5165\uff0c\u4ed6\u4eec\u901a\u8fc7\u5206\u79bb\u4e2d\u95f4\u4f53\u8fdb\u884c\u6c22\u5316\u5b9e\u9a8c\u7b49\u65b9\u5f0f\u53d1\u73b0\uff0c\u914d\u4f53\u4e0e\u78b1\u5f62\u6210\u6c2e\u8d1f\u79bb\u5b50-\u78b1\u91d1\u5c5e\u76d0\u4e4b\u540e\u5f80\u5f80\u53cd\u5e94\u6d3b\u6027\u66f4\u9ad8\u3002\u56e0\u4e3a\u78b1\u91d1\u5c5e\u79bb\u5b50\u53ef\u4ee5\u7a33\u5b9a\u91d1\u5c5e\u6c22\u7269\u79cd\u4e0e\u5e95\u7269\u7684\u52a0\u5408\u7269\uff0c\u800c\u4e14\u8d1f\u79bb\u5b50\u7684\u5f62\u6210\u8fd8\u80fd\u4f7f\u5f97\u914d\u4f53\u66f4\u5bcc\u7535\u5b50\uff0c\u589e\u5f3a\u4e86\u91d1\u5c5e\u4e0a\u6c22\u8d1f\u7684\u4eb2\u6838\u80fd\u529b\uff0c\u5b9e\u73b0\u4e86\u78b1\u91d1\u5c5e\u79bb\u5b50\u4ecb\u5bfc\u7684\u03c0\u8f68\u9053\u65b9\u5411\u6d3b\u5316^{[8]<\/sup>\u3002<\/strong><\/p>\n}
Fig.4. <\/strong>Alkali metal ion-mediated \u03c0-activation with the C=N\/C=O double bond in the substrate,<\/p>\n
\u4f7f\u7528Lewis\u9178\u6216\u8d28\u5b50\u9178\u6765\u6d3b\u5316\u6781\u6027\u53cc\u952e\u662f\u975e\u5e38\u5e38\u89c1\u7684\u505a\u6cd5\uff0c\u5728\u5916\u7403\u673a\u7406\u6a21\u578b\u548c\u78b1\u91d1\u5c5e\u79bb\u5b50\u4ecb\u5bfc\u7684\u03c0\u8f68\u9053\u65b9\u5411\u6d3b\u5316\u6a21\u578b\u4e2d\uff0c\u50ac\u5316\u5242\u4e2d\u7684\u8d28\u5b50\u6c22\u6216\u8005\u78b1\u91d1\u5c5e\u79bb\u5b50\u76f4\u63a5\u4e0e\u5e95\u7269\u6781\u6027\u53cc\u952e\u4e2d\u7684\u6c2e\/\u6c27\u4f5c\u7528\uff0c\u6709\u4f5c\u4e3a\u9178\u6d3b\u5316\u6781\u6027\u53cc\u952e\u7684\u53ef\u80fd\u6027\u3002\u4f46\u662f\u4e0a\u8ff0\u4e24\u79cd\u6a21\u578b\u4e2d\u8d28\u5b50\u6c22\u6216\u78b1\u91d1\u5c5e\u79bb\u5b50\u901a\u5e38\u53ea\u80fd\u548c\u5e95\u7269\u7684\u03c0\u8f68\u9053\u65b9\u5411\u800c\u4e0d\u662f\u03c3-\u8f68\u9053\u65b9\u5411\u4f5c\u7528\uff0c\u96be\u4ee5\u53d1\u6325\u51fa\u9178\u7684\u529f\u80fd\u3002\u57fa\u4e8e\u6b64\u6e05\u534e\u5927\u5b66\u5218\u5f3a\u63d0\u51fa\u4e86\u03c3-\u8bf1\u5bfc\u6d3b\u5316^{[9]<\/sup>\uff0c\u5373\u901a\u8fc7\u8c03\u63a7\u91d1\u5c5e\u9633\u79bb\u5b50\uff0c\u4f7f\u5176\u4e0e\u5e95\u7269\u6c2e\/\u6c27\u7684\u03c3-\u952e\u65b9\u5411\u5b64\u7535\u5b50\u5bf9\u4f5c\u7528\uff0c\u63d0\u9ad8\u4e86\u5e95\u7269\u7684\u4eb2\u7535\u80fd\u529b\uff0c\u5927\u5927\u63d0\u5347\u4e86\u6c22\u8d1f\u8f6c\u79fb\u7684\u6548\u7387\u3002<\/strong><\/p>\n}
<\/strong><\/p>\n
Fig. 5. <\/strong>Comparison of catalytic activity of HMn-NH, HMn-NLi, and HMn-NAl systems.<\/p>\n
\u4e0a\u8ff0\u673a\u7406\u4e0a\u7684\u94fa\u57ab\u542f\u53d1\u7740\u79d1\u5b66\u5bb6\u4eec\u5bf9\u4e8e\u4e0d\u5bf9\u79f0\u53cd\u5e94\u7684\u63a2\u7d22\u3002\u5411\u9530\u7edc\u5408\u7269\u4e2d\u5f15\u5165\u624b\u6027\u5143\u7d20\uff0c\u4fbf\u6709\u673a\u4f1a\u5b9e\u73b0\u9530\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u3002\u5411\u9530\u7edc\u5408\u7269\u4e2d\u5f15\u5165\u624b\u6027\u5143\u7d20\u4e3b\u8981\u6709\u4e24\u79cd\u65b9\u5f0f\uff0cBeller\u3001\u4e01\u594e\u5cad\u7b49^{[10] [11]<\/sup>\u5c06\u914d\u4f53\u81a6\u7684\u90e8\u5206\u505a\u6210\u624b\u6027\u7684BPE\u7247\u6bb5\uff0c\u5f97\u5230\u4e86\u7ecf\u5f0f\u914d\u4f4d\u7684\u9530\u7edc\u5408\u7269\uff1bKirchner\u3001\u5218\u5f3a^{[12] [13] [14] [15]<\/sup>\u7b49\u5219\u4ee5\u4e8c\u8302\u94c1\u4e3a\u57fa\u7840\uff0c\u7531\u4e8c\u8302\u94c1\u5f15\u5bfc\u914d\u4f53\u5728\u91d1\u5c5e\u4e0a\u53d1\u751f\u9762\u5f0f\u6298\u53e0\uff0c\u5b9e\u73b0\u914d\u4f53\u9762\u624b\u6027\u5230\u91d1\u5c5e\u7684\u4e2d\u5fc3\u624b\u6027\u518d\u5230\u4ea7\u7269\u624b\u6027\u7684\u4f20\u9012\u3002<\/strong><\/p>\n}}
Fig. 6. <\/strong>Some design of chiral ligands<\/p>\n
\u5218\u5f3a\u8bfe\u9898\u7ec4\u6839\u636e\u201c\u5c0f\u4f4d\u963b\uff0c\u5bcc\u7535\u5b50\u201d\u8fd9\u4e00\u539f\u5219\u53d1\u5c55\u4e86\u9ad8\u6d3b\u6027\u7684PNN-Mn\u7edc\u5408\u7269\uff0c\u5b9e\u73b0\u4e86\u55b9\u5549\u30013,3-\u4e8c\u53d6\u4ee33-H\u5432\u54da\u3001\u55b9\u5594\u5549\u7b49\u5e95\u7269\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316^{[12] [13]<\/sup>^{[14]<\/sup>\u3002<\/p>\n}}
\u5728\u5bf9\u55b9\u5549\u8fdb\u884c\u4e0d\u5bf9\u79f0\u6c22\u5316\u65f6\uff0c\u914d\u4f53\u4e0a\u7684N-H\u90e8\u5206\u53ef\u4ee5\u901a\u8fc7\u91d1\u5c5e-\u914d\u4f53\u534f\u540c\u4f5c\u7528\u663e\u8457\u5f71\u54cd\u50ac\u5316\u6c22\u5316\u53cd\u5e94\u7684\u53cd\u5e94\u6027\uff0c\u5f53\u914d\u4f53\u70f7\u57fa\u6c2e\u4e0a\u7684\u6c22\u88ab\u7532\u57fa\u53d6\u4ee3\u65f6\uff0c\u50ac\u5316\u5242\u7684\u53cd\u5e94\u6d3b\u6027\u6025\u5267\u4e0b\u964d\u3002\u800c\u54aa\u5511\u6c2e\u4e0a\u7684\u6c22\u88ab\u7532\u57fa\u53d6\u4ee3\u65f6\u53cd\u5e94\u6d3b\u6027\u548c\u9009\u62e9\u6027\u4e5f\u53d1\u751f\u4e86\u4e0b\u964d\u3002\u54aa\u5511\u4e0e\u55b9\u5549\u7684\u82ef\u5e76\u73af\u4e4b\u95f4\u5b58\u5728\u03c0-\u03c0\u76f8\u4e92\u4f5c\u7528\uff0c\u5b9e\u73b0\u4e86\u55b9\u5549\u50ac\u5316\u6c22\u5316\u7684\u624b\u6027\u63a7\u5236\u3002<\/strong><\/p>\n
Fig. 7. <\/strong>Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by \u03c0\u2013\u03c0 Interaction<\/p>\n
\u4f7f\u7528Noyori-Ikariya\u50ac\u5316\u5242\u6c22\u53163,3-\u4e8c\u53d6\u4ee33-H\u5432\u54da\u65f6\uff0c\u751f\u6210\u91d1\u5c5e\u6c22\u7269\u79cd\u7684\u540c\u65f6\u4f1a\u751f\u6210\u7b49\u91cf\u7684\u8d28\u5b50\uff0c\u4f7f\u4e9a\u80fa\u6c2e\u88ab\u8d28\u5b50\u5316\u3002\u8d28\u5b50\u5316\u7684\u4e9a\u80fa\u6d3b\u6027\u6bd4\u8f83\u9ad8\uff0c\u5f88\u5feb\u5c31\u4f1a\u88ab\u948c-\u6c22\u7269\u79cd\u6c22\u5316\u3002\u5982\u679c\u5e95\u7269\u4e2d\u542b\u6709\u5421\u5576\u57fa\u56e2\uff0c\u751f\u6210\u7684\u8d28\u5b50\u4f1a\u8f6c\u79fb\u5230\u5421\u5576\u6c2e\u4e0a\uff0c\u964d\u4f4e\u4e86\u5e95\u7269\u7684\u6d3b\u6027\uff0c\u8fd9\u65f6\u4f7f\u7528Noyori-Ikariya\u578b\u50ac\u5316\u5242\u5c31\u96be\u4ee5\u5b9e\u73b0\u5bf93,3-\u4e8c\u53d6\u4ee33-H\u5432\u54da\u7684\u6c22\u5316\u3002\u800c\u4f7f\u7528PNN-Mn\u50ac\u5316\u5242\u65f6\uff0c\u56e0\u4e3a\u9530-\u6c22\u7269\u79cd\u6d3b\u6027\u9ad8\uff0c\u4e0d\u9700\u8981\u5c06\u4e9a\u80fa\u8d28\u5b50\u5316\u5c31\u80fd\u5b9e\u73b0\u5e95\u7269\u7684\u6c22\u5316\u3002<\/strong><\/p>\n
Fig. 8.<\/strong> Manganese-Catalyzed Asymmetric Hydrogenation of\u00a03H<\/em>-Indoles<\/p>\n
\u5218\u5f3a\u8bfe\u9898\u7ec4\u53d1\u73b0\u4f7f\u7528PNN-Mn\u7edc\u5408\u7269\u8fdb\u884c\u55b9\u5594\u5549\u4e0d\u5bf9\u79f0\u6c22\u5316\u65f6\uff0c\u901a\u8fc7\u63a7\u5236\u53cd\u5e94\u6761\u4ef6\u53ef\u4ee5\u5b9e\u73b0\u5206\u522b\u5f97\u5230\u987a\u5f0f\u6216\u53cd\u5f0f\u7684\u6c22\u5316\u4ea7\u7269\uff0c\u53cd\u5e94\u5206\u4e24\u6b65\u5c06\u4e24\u4e2a\u53cc\u952e\u5206\u522b\u6c22\u5316\uff0c\u7b2c\u4e8c\u6b65\u6c22\u5316\u65f6\u50ac\u5316\u5242\u8fdb\u653b\u7684\u9762\u51b3\u5b9a\u4e86\u4ea7\u7269\u7684\u987a\u53cd\u3002\u4f7f\u7528\u666e\u901a\u6eb6\u5242\u65f6\u94a0\u79bb\u5b50\u5728\u914d\u4f53\u7684\u54aa\u5511\u73af\u548c\u5e95\u7269\u7684\u82ef\u5e76\u73af\u4e4b\u95f4\u7684\u9633\u79bb\u5b50-\u03c0\u76f8\u4e92\u4f5c\u7528\u8d77\u5230\u4e86\u5b9a\u4f4d\u7684\u529f\u80fd\uff0c\u914d\u4f53\u63a7\u5236\u4e86\u53e6\u4e00\u4e2a\u53cc\u952e\u6c22\u5316\u7684\u624b\u6027\u5c31\u5f97\u5230\u4e86\u53cd\u5f0f\u4ea7\u7269\u3002\u800c\u4f7f\u752815-\u51a0-5\u4f5c\u4e3a\u6eb6\u5242\u65f6\uff0c\u94a0\u79bb\u5b50\u88ab\u675f\u7f1a\uff0c\u9633\u79bb\u5b50-\u03c0\u4f5c\u7528\u6d88\u5931\uff0c\u7b2c\u4e8c\u6b65\u53cc\u952e\u6c22\u5316\u66f4\u503e\u5411\u4e8e\u4ece\u4f4d\u963b\u5c0f\u7684\u4e00\u4fa7\u63a5\u8fd1\uff0c\u4ece\u800c\u751f\u6210\u987a\u5f0f\u7684\u4ea7\u7269\u3002<\/strong><\/p>\n
Fig. 9. <\/strong>Stereodivergent asymmetric hydrogenation of quinoxalines<\/p>\n
\u8fd1\u65e5\uff0c\u5218\u5f3a\u8bfe\u9898\u7ec4\u6210\u529f\u5c06\u03c3-\u8bf1\u5bfc\u6d3b\u5316\u4f5c\u7528\u5f15\u5165\u4e86\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u4e2d\uff0c\u5b9e\u73b0\u4e86\u5728\u4e9a\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u5316\u4e2d\u7532\u57fa\u4e59\u57fa\u3001\u4ee5\u53ca\u6bd4\u7532\u57fa\u4e59\u57fa\u66f4\u96be\u7684\u4e19\u57fa\u4e01\u57fa\u7684\u533a\u5206^{[15]<\/sup>\u3002<\/p>\n}
<\/strong><\/p>\n
Fig. 10. <\/strong>Control experiments including sodium cation capture, the change of base and solvent<\/p>\n
\u5411\u4f53\u7cfb\u4e2d\u52a0\u516515-\u51a0-5\u4f1a\u4f7f\u4f7fee\u503c\u5927\u5e45\u964d\u4f4e\uff0c\u91d1\u5c5e\u79bb\u5b50\u7531\u94a0\u6362\u6210\u94be\u4e5f\u5bfc\u81f4\u4e86ee\u503c\u7684\u964d\u4f4e\uff0c\u8bf4\u660e\u94a0\u79bb\u5b50\u5728\u624b\u6027\u63a7\u5236\u4e2d\u8d77\u5230\u4e86\u6781\u4e3a\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n
<\/strong><\/p>\n
Fig. 11. <\/strong>Four hydride transfer transition states involving sodium cations. For hydride transfer transition states via \u03c3-coordination interactions, Z-S-TS4 is favored over E-R-TS6 by 2.2 kcal mol^{-1<\/sup>; For hydride transfer transition states via cation-\u03c0 interactions, the energy barriers via E-S-TS8 and Z-R-TS9 are 15.4 kcal mol^{-1<\/sup> higher than that via the favorable transition state Z-S-TS4.<\/p>\n}}
\u8ba1\u7b97\u8868\u660e\uff0c\u94a0\u79bb\u5b50\u4e0e\u914d\u4f53\u7684\u54aa\u5511\u57fa\u56e2\u5e76\u4e0d\u5904\u4e8e\u540c\u4e00\u5e73\u9762\u5185\uff0c\u800c\u662f\u7565\u9ad8\u4e8e\u54aa\u5511\u73af\u7684\u5e73\u9762\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u5728\u5e95\u7269\u6c2e\u5728\u03c3-\u952e\u65b9\u5411\u4e0a\u7684\u03c3-\u8bf1\u5bfc\u6d3b\u5316\uff0c\u9664\u6b64\u4ee5\u5916\uff0c\u5e95\u7269\u82ef\u73af\u4e0a\u7684\u7532\u6c27\u57fa\u4e0e\u94a0\u79bb\u5b50\u7684\u914d\u4f4d\u4e5f\u5bf9\u5e95\u7269\u53d6\u5411\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u540c\u65f6\u914d\u4f53\u6c2e\u4e0a\u7684\u6c22\u4e0e\u91d1\u5c5e\u6c22\u4ece\u03c0\u952e\u7684\u65b9\u5411\u63a5\u8fd1\u5e95\u7269\uff0c\u5b9e\u73b0\u4e86\u5e95\u7269\u5728\u03c0-\u952e\u65b9\u5411\u7684\u6d3b\u5316\u3002\u4e8c\u6c27\u516d\u73af\u4e0e\u94a0\u79bb\u5b50\u914d\u4f4d\u5f62\u6210\u4e86\u5de8\u5927\u7684\u4f4d\u963b\uff0c\u8ba9\u5e95\u7269\u4e2d\u8f83\u5927\u7684\u57fa\u56e2\u8fdc\u79bb\u94a0\u79bb\u5b50\u7684\u65b9\u5411\u3002\u50ac\u5316\u5242\u5728\u4e9a\u80faC=N\u53cc\u952e\u03c3-\u8f68\u9053\u65b9\u5411\u548c\u03c0-\u8f68\u9053\u65b9\u5411\u5171\u540c\u5bf9\u5e95\u7269\u4f5c\u7528\uff0c\u5b9e\u73b0\u4e86\u5f3a\u5927\u7684\u6d3b\u5316\u80fd\u529b\u548c\u7acb\u4f53\u63a7\u5236\u80fd\u529b\u3002\u800c\u5f53\u91d1\u5c5e\u79bb\u5b50\u6362\u6210\u94be\u65f6\uff0c\u7531\u4e8e\u94be\u7684\u534a\u5f84\u66f4\u5927\uff0c\u50ac\u5316\u5242\u7684\u7acb\u4f53\u63a7\u5236\u80fd\u529b\u968f\u4e4b\u964d\u4f4e\uff0c\u4e0d\u5bf9\u79f0\u6c22\u5316\u7684\u7acb\u4f53\u9009\u62e9\u6027\u4e5f\u968f\u4e4b\u4e0b\u964d\u3002<\/p>\n
\u603b\u7ed3<\/strong><\/h4>\n
\u9530\u50ac\u5316\u6c22\u5316\u867d\u7136\u53d1\u5c55\u6bd4\u8f83\u665a\uff0c\u4f46\u662f\u8fd1\u51e0\u5e74\u7684\u53d1\u5c55\u4e5f\u6bd4\u8f83\u8fc5\u901f\uff0c\u4eba\u4eec\u5bf9\u673a\u7406\u7684\u8ba4\u8bc6\u4ece\u6700\u65e9\u7b80\u5355\u7684\u5916\u7403\u673a\u7406\uff0c\u5230\u78b1\u91d1\u5c5e\u79bb\u5b50\u4ecb\u5bfc\u7684\u03c0-\u8f68\u9053\u65b9\u5411\u6d3b\u5316\uff0c\u518d\u5230\u03c3-\u8bf1\u5bfc\u6d3b\u5316\uff0c\u914d\u4f53\u4e5f\u4ece\u7b80\u5355\u7684\u6d88\u65cbPNP\u914d\u4f53\u9010\u6b65\u53d1\u5c55\u4e3a\u5177\u6709\u5f3a\u5927\u7acb\u4f53\u9009\u62e9\u6027\u548c\u50ac\u5316\u6d3b\u6027\u7684\u4e8c\u8302\u94c1PNN\u914d\u4f53\uff0c\u5747\u76f8\u9530\u50ac\u5316\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u5728\u53cd\u5e94\u6d3b\u6027\u548c\u4e0d\u5bf9\u79f0\u9009\u62e9\u6027\u4e0a\u663e\u793a\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n
\u00a0<\/strong>\uff08\u975e\u5e38\u611f\u8c22\u5218\u5f3a\u6559\u6388\u8bfe\u9898\u7ec4\u738b\u660e\u626c\u535a\u58eb\u5bf9\u672c\u6587\u7684\u6307\u5bfc\uff09<\/strong><\/p>\n
\u53c2\u8003\u6587\u732e<\/strong>\uff1a<\/h4>\n
\n
[1]\u00a0 Saravanakumar Elangovan, Christoph Topf, Steffen Fischer, Haijun Jiao, Anke Spannenberg, Wolfgang Baumann, Ralf Ludwig, Kathrin Junge, and Matthias Beller*, Selective Catalytic Hydrogenations of Nitriles, Ketones, and Aldehydes by Well-Defined Manganese Pincer Complexes,J. Am. Chem. Soc.<\/em>2016<\/strong>, 138, 8809\u20138814.<\/li>\n

[2]\u00a0 Fabian Kallmeier, Torsten Irrgang, Thomas Dietel, Rhett Kempe*, Highly Active and Selective Manganese C=O Bond Hydrogenation Catalysts: The Importance of the Multidentate Ligand, the Ancillary Ligands, and the Oxidation State,Angew. Chem. Int. Ed.<\/em>2016<\/strong>, 55, 11806\u201311809.<\/li>\n

[3]\u00a0 Saravanakumar Elangovan, Marcel Garbe, Haijun Jiao, Anke Spannenberg, Kathrin Junge, Matthias Beller*, Hydrogenation of Esters to Alcohols Catalyzed by Defined Manganese Pincer Complexes,Angew. Chem. Int. Ed.<\/em>2016<\/strong>, 55, 15364\u201315368.<\/li>\n

[4]\u00a0 Marcel Garbe, Kathrin Junge, Svenja Walker, Zhihong Wei, Haijun Jiao, Anke Spannenberg, Stephan Bachmann, Michelangelo Scalone, Matthias Beller*, Manganese(I)-Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand,Angew. Chem. Int. Ed.<\/em>2017<\/strong>, 56, 11237\u201311241.<\/li>\n

[5]\u00a0 Magnus B. Widegren, Gavin J. Harkness, Alexandra M. Z. Slawin*, David B. Cordes*, Matthew L. Clarke*, A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation,Angew. Chem. Int. Ed.<\/em>2017<\/strong>, 56, 5825\u20135828.<\/li>\n

[6]\u00a0 M.\u2005Sc. Viktoriia Zubar, Yury Lebedev, Luis Miguel Azofra, Luigi Cavallo*, Osama El-Sepelgy*, Magnus Rueping*,\u00a0Hydrogenation of CO2-Derived Carbonates and Polycarbonates to Methanol and Diols by Metal\u2013Ligand Cooperative Manganese Catalysis,Angew. Chem. Int. Ed.<\/em>\u00a02018<\/strong>,\u00a057, 13439.<\/li>\n

[7]\u00a0 Yujie Wang, Lei Zhu, Zhihui Shao, Gang Li, Yu Lan*, and Qiang Liu*, Unmasking the Ligand Effect in Manganese-Catalyzed Hydrogenation: Mechanistic Insight and Catalytic Application,J. Am. Chem. Soc.<\/em>2019<\/strong>,141<\/em>, 17337\u201317349.<\/li>\n

[8]\u00a0 Yujie Wang, Shihan Liu, Haobo Yang, Hengxu Li, Yu Lan*, and Qiang Liu*, Structure, reactivity and catalytic properties of manganese-hydride amidate complexes,Nat. Chem.<\/em>2022<\/strong>,14<\/em>, 1233\u20131241.<\/li>\n

[9]\u00a0 Shihan Liu, Haobo Yang, Ya-Nan Wang, Qiaoqiao Zhao, Yujie Wang*, Ruopeng Bai*, Qiang Liu*, and Yu Lan*, \u00a0Enhancing Hydride Transfer in Catalytic Hydrogenation via \u03c3-Electron-Induced Polarization of Imines,J. Am. Chem. Soc.<\/em>2024<\/strong>, 146, 24, 16357\u201316362.<\/li>\n

[10] Marcel Garbe, Kathrin Junge, Svenja Walker, Zhihong Wei, Haijun Jiao, Anke Spannenberg, Stephan Bachmann, Michelangelo Scalone, Matthias Beller*,\u00a0Manganese(I)-Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand,Angew. Chem. Int. Ed.<\/em>\u00a02017<\/strong>,\u00a056, 11237.<\/li>\n

[11] Linli Zhang, Yitian Tang, Zhaobin Han, Kuiling Ding*, Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones,Angew. Chem. Int. Ed.<\/em>2019<\/strong>, 58, 4973\u20134977.<\/li>\n

[12] Chenguang Liu, Mingyang Wang, Shihan Liu, Yujie Wang, Yong Peng, Yu Lan*, Qiang Liu*, Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by \u03c0\u2013\u03c0 Interaction,Angew. Chem. Int. Ed.<\/em>2021<\/strong>, 60, 5108\u20135113.<\/li>\n

[13] Chenguang Liu, Mingyang Wang, Yihan Xu, Yibiao Li, Qiang Liu*, Manganese-Catalyzed Asymmetric Hydrogenation of 3H-Indoles,Angew. Chem. Int. Ed.<\/em>2022<\/strong>, 61, e202202814.<\/li>\n

[14] Chenguang Liu, Xufang Liu, Qiang Liu*,Chem<\/em>2023<\/strong>, 9, 2585\u20132600.<\/li>\n

[15] Mingyang Wang, Shihan Liu, Hao Liu, Yujie Wang, Yu Lan* and Qiang Liu*, Asymmetric hydrogenation of ketimines with minimally different alkyl groups,Nature <\/em>2024<\/strong>, 1\u20132.<\/li>\n<\/ul>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u4f5c\u8005\uff1aAzathoth \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u5199\u4f5c\u6307\u5bfc\uff1aCyclization Xu \u5bfc\u8bfb\uff1a \u672c\u6587\u4ecb\u7ecd\u4e86\u9530\u50ac\u5316\u6c22\u5316\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u6587\u4e2d\u63cf\u8ff0\u4e86\u4e0d\u540c\u7c7b\u578b\u9530\u50ac\u5316\u5242\u7684\u8bbe\u8ba1\u4e0e\u6027\u80fd\uff0c\u901a\u8fc7\u5206\u6790\u4e0d\u540c\u914d\u4f53\u548c\u53cd\u5e94\u6761\u4ef6\u5bf9\u50ac\u5316\u6548\u7387\u548c\u9009\u62e9\u6027\u7684\u5f71\u54cd\uff0c\u5c55\u793a\u4e86\u9530\u50ac\u5316\u5242\u5728\u4e0d\u5bf9\u79f0\u6c22\u5316\u53cd\u5e94\u4e2d\u7684\u6f5c\u529b\u3002\u6e05\u534e\u5927\u5b66\u5218\u5f3a\u56e2\u961f\u63d0\u51fa\u4e86\u5173\u4e8e\u9530\u50ac\u5316\u6c22\u5316\u7684\u591a\u79cd\u6d3b\u5316\u6a21\u578b\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u5728\u50ac\u5316\u5242\u7684\u8bbe\u8ba1\u4e0a\uff0c\u63a8\u52a8\u4e86\u8be5\u9886\u57df\u7684\u5feb\u901f\u53d1\u5c55\u3002 \u6b63\u6587\uff1a \u9530\u662f\u4ec5\u6b21\u4e8e\u94c1\u3001\u949b\uff0c\u50a8\u91cf\u6392\u7b2c\u4e09\u4f4d\u7684\u8fc7\u6e21\u91d1\u5c5e\uff0c\u5177\u6709\u5f88\u5927\u7684\u5e94\u7528\u4ef7\u503c\u3002\u63d0\u5230\u9530\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u53cd\u5e94\uff0c\u6211\u4eec\u9996\u5148\u60f3\u5230\u7684\u5c31\u662f\u8bfe\u672c\u4e0a\u7684Jacobsen\u2013Katsuki\u4e0d\u5bf9\u79f0\u73af\u6c27\u5316\u3002\u4f46\u662f\u5747\u76f8\u9530\u50ac\u5316\u7684\u6c22\u5316\u4e00\u76f4\u52302016\u5e74\u624d\u5f00\u59cb\u53d1\u5c55\uff0c\u5c5e\u4e8e\u4e00\u4e2a\u6bd4\u8f83\u65b0\u7684\u9886\u57df\u3002\u76ee\u524d\u7684\u5df2\u77e5\u7684\u9530\u50ac\u5316\u6c22\u5316\u90fd\u662f\u5916\u7403\u673a\u7406\uff0c\u5bf9\u4e8e\u5916\u7403\u673a\u7406\u7684\u91d1\u5c5e\u50ac\u5316\u4e0d\u5bf9\u79f0\u6c22\u5316\u800c\u8a00\uff0c\u53cd\u5e94\u6700\u91cd\u8981\u7684\u4e24\u6b65\u662f\u91d1\u5c5e\u6c22\u7269\u79cd\u7684\u751f\u6210\u548c\u6c22\u8d1f\u7684\u8f6c\u79fb\u3002\u4f46\u8fd9\u4e24\u6b65\u7684\u5f71\u54cd\u56e0\u7d20\u5f80\u5f80\u662f\u76f8\u4e92\u77db\u76fe\u7684\uff0c\u91d1\u5c5e\u6c22\u7269\u79cd\u7684\u6d3b\u6027\u8d8a\u9ad8\uff0c\u6c22\u8d1f\u8d8a\u5bb9\u6613\u8f6c\u79fb\uff0c\u7136\u800c\u4e5f\u610f\u5473\u7740\u91d1\u5c5e\u6c22\u7269\u79cd\u4e5f\u5c31\u8d8a\u96be\u751f\u6210\u3002\u5bf9\u4e8e\u948c\u94d1\u7b49\u9760\u540e\u7684\u8fc7\u6e21\u91d1\u5c5e\u800c\u8a00\uff0c\u5b83\u4eec\u7684\u91d1\u5c5e\u6c22\u7269\u79cd\u751f\u6210\u548c\u6c22\u8d1f\u8f6c\u79fb\u6070\u597d\u8fbe\u5230\u4e86\u4e00\u4e2a\u5e73\u8861\uff0c\u91d1\u5c5e\u6c22\u7269\u79cd\u65e2\u5bb9\u6613\u751f\u6210\u4e5f\u5bb9\u6613\u4e0e\u5e95\u7269\u53d1\u751f\u53cd\u5e94\u3002\u800c\u5bf9\u4e8e\u7b2c\u4e00\u884c\u8fc7\u6e21\u91d1\u5c5e\u800c\u8a00\uff0c\u91d1\u5c5e\u6c22\u7269\u79cd\u7684\u6d3b\u6027\u975e\u5e38\u9ad8\uff0c\u867d\u7136\u8fd9\u610f\u5473\u7740\u5f3a\u5927\u7684\u53cd\u5e94\u6d3b\u6027\uff0c\u4f46\u540c\u65f6\u4e5f\u5bfc\u81f4\u4e86\u91d1\u5c5e\u6c22\u7269\u79cd\u975e\u5e38\u96be\u4ee5\u751f\u6210\u3002 Fig.1. Typical outer-sphere mechanism catalytic hydrogenation \u76ee\u524d\u516c\u8ba4\u6700\u65e9\u7684\u5747\u76f8\u9530\u50ac\u5316\u6c22\u5316\u662f\u7531Beller \u7b49\u4eba\u5b9e\u73b0\u7684[1]\uff0c\u4ed6\u4eec\u7528PNP\u4e09\u9f7f\u914d\u4f53\u548c\u9530\u7684\u7edc\u5408\u7269\u5b9e\u73b0\u4e86\u82ef\u8148\u3001\u919b\u3001\u916e\u7684\u6c22\u5316\u3002Beller\u7684\u7814\u7a76\u8868\u660e\uff0c\u9530\u50ac\u5316\u5242\u5fc5\u987b\u8981\u6709\u4e00\u6c27\u5316\u78b3\u914d\u4f4d\uff0c\u901a\u8fc7\u53cd\u4f4d\u6548\u5e94\u6765\u7a33\u5b9a\u9530-\u6c22\u952e\uff0c\u5426\u5219\u9530\u6c22\u7269\u79cd\u7684\u80fd\u91cf\u4f1a\u975e\u5e38\u9ad8\uff0c\u96be\u4ee5\u751f\u6210\uff0c\u4ece\u800c\u65e0\u6cd5\u5b9e\u73b0\u50ac\u5316\u6c22\u5316\u3002 Scheme 1. One of the earliest homogeneous manganese-catalyzed hydrogenation reactions: hydrogenation of nitriles.Fig.2. Mechanism of manganese-catalyzed hydrogenation \u5f71\u54cd\u53cd\u5e94\u6d3b\u6027\u65e0\u5916\u4e4e\u4e24\u4e2a\u4e3b\u8981\u539f\u56e0\uff1a\u7a7a\u95f4\u4f4d\u963b\u548c\u7535\u5b50\u6548\u5e94\u3002\u5bf9\u4e8e\u5747\u76f8\u7684\u9530\u50ac\u5316\u6c22\u5316\u53cd\u5e94\u800c\u8a00\uff0c\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u66f4\u5bcc\u7535\u5b50\u3001\u66f4\u5c0f\u4f4d\u963b\u7684\u50ac\u5316\u5242\u62e5\u6709\u76f8\u5bf9\u66f4\u9ad8\u7684\u6d3b\u6027\u3002\u5c0f\u7684\u4f4d\u963b\u6709\u5229\u4e8e\u50ac\u5316\u5242\u4e0e\u5e95\u7269\u63a5\u8fd1\uff0c\u800c\u5bcc\u7535\u5b50\u6709\u5229\u4e8e\u63d0\u9ad8\u91d1\u5c5e\u6c22\u7269\u79cd\u7684\u4eb2\u6838\u80fd\u529b\u3002\u5982Kempt\u7684\u5de5\u4f5c\u6240\u793a\uff0c\u5f53\u5421\u5576\u914d\u4f4d\u57fa\u56e2\u7684\u5bf9\u4f4d\u6709\u6c28\u57fa\u53d6\u4ee3\u65f6\uff0c\u50ac\u5316\u5242\u7684\u6d3b\u6027\u4f1a\u5f97\u5230\u63d0\u5347[2]\u3002Beller\u540e\u7eed\u7684\u5de5\u4f5c\u4e5f\u663e\u793a\u4e86\u4f4d\u963b\u5bf9\u50ac\u5316\u5242\u6d3b\u6027\u7684\u5f71\u54cd[3]\u3002Scheme 2. The enhancement of the electron-donating ability of the ligand is beneficial for improving catalytic activity. Scheme 3. The reduction of ligand steric hindrance is beneficial for improving catalytic activity. Beller \u3001Clarke\u3001Rueping\u3001Balskus\u7b49\u4eba\u5206\u522b\u4ee5\u54aa\u5511\u3001\u5421\u5576\u4e3a\u914d\u4f4d\u57fa\u56e2\u8bbe\u8ba1\u4e86PNN\u914d\u4f53[4] [5] [6]\uff0cPNN-Mn\u7684\u50ac\u5316\u6d3b\u6027\u76f8\u5bf9\u4e8ePNP-Mn\u50ac\u5316\u5242\u6709\u5de8\u5927\u7684\u63d0\u5347\u3002PNN-Mn\u50ac\u5316\u5242\u53ef\u4ee5\u6c22\u5316\u5982\u9170\u80fa\u3001\u916f\u548c\u78b3\u9178\u916f\u8fd9\u4e9b\u5177\u6709\u5f88\u5927\u6311\u6218\u6027\u7684\u5e95\u7269\uff0c\u8fd9\u662f\u5f88\u591aPNP-Mn\u50ac\u5316\u5242\u96be\u4ee5\u5b9e\u73b0\u7684\u3002 Scheme 4. In most cases, PNN ligands exhibit higher reaction activity than PNP ligands. \u540e\u6765\u6e05\u534e\u5927\u5b66\u5218\u5f3a\u548c\u91cd\u5e86\u5927\u5b66\u84dd\u5b87\u89e3\u91ca\u4e86PNN-Mn\u7edc\u5408\u7269\u6d3b\u6027\u5f3a\u4e8ePNP-Mn\u7edc\u5408\u7269\u7684\u539f\u56e0\uff1a\u4ed6\u4eec\u8ba4\u4e3aPNN\u914d\u4f53\u76f8\u5bf9\u4e8ePNP\u914d\u4f53\u7684\u4f18\u52bf\u5728\u4e8e\u4f4d\u963b\u5c0f\u3001\u5bcc\u7535\u5b50\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u6c22\u5316\u53cd\u5e94\u7684\u80fd\u5792[7]\u3002 Fig.3. Reasons for higher activity of PNN ligands: reduced steric hindrance, electron-rich nature, lowering the energy of substrate-catalyst adducts, facilitating easier reactions. \u968f\u7740\u4ee5\u4e0a\u7814\u7a76\u7684\u6df1\u5165\uff0c\u4ed6\u4eec\u901a\u8fc7\u5206\u79bb\u4e2d\u95f4\u4f53\u8fdb\u884c\u6c22\u5316\u5b9e\u9a8c\u7b49\u65b9\u5f0f\u53d1\u73b0\uff0c\u914d\u4f53\u4e0e\u78b1\u5f62\u6210\u6c2e\u8d1f\u79bb\u5b50-\u78b1\u91d1\u5c5e\u76d0\u4e4b\u540e\u5f80\u5f80\u53cd\u5e94\u6d3b\u6027\u66f4\u9ad8\u3002\u56e0\u4e3a\u78b1\u91d1\u5c5e\u79bb\u5b50\u53ef\u4ee5\u7a33\u5b9a\u91d1\u5c5e\u6c22\u7269\u79cd\u4e0e\u5e95\u7269\u7684\u52a0\u5408\u7269\uff0c\u800c\u4e14\u8d1f\u79bb\u5b50\u7684\u5f62\u6210\u8fd8\u80fd\u4f7f\u5f97\u914d\u4f53\u66f4\u5bcc\u7535\u5b50\uff0c\u589e\u5f3a\u4e86\u91d1\u5c5e\u4e0a\u6c22\u8d1f\u7684\u4eb2\u6838\u80fd\u529b\uff0c\u5b9e\u73b0\u4e86\u78b1\u91d1\u5c5e\u79bb\u5b50\u4ecb\u5bfc\u7684\u03c0\u8f68\u9053\u65b9\u5411\u6d3b\u5316[8]\u3002 Fig.4. Alkali metal ion-mediated \u03c0-activation […]","protected":false},"author":26,"featured_media":50997,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[624,4419,4418,4417],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/08\/2382c315a6ba396be1932dd8dafaff52-1.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-dgw","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50996"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=50996"}],"version-history":[{"count":7,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50996\/revisions"}],"predecessor-version":[{"id":51038,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50996\/revisions\/51038"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/50997"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=50996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=50996"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=50996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":50990,"date":"2024-08-26T08:34:54","date_gmt":"2024-08-26T00:34:54","guid":{"rendered":"\/\/www.gsbet888.com\/?p=50990"},"modified":"2024-08-26T08:37:52","modified_gmt":"2024-08-26T00:37:52","slug":"%e7%bb%b4%e5%b0%94%e8%8c%a8%e5%a0%a1%e5%a4%a7%e5%ad%a6jake-l-greenfield%e7%bb%84%e6%8b%9b%e8%81%98%e5%90%af%e4%ba%8b","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemnews\/%e6%8b%9b%e8%81%98%e4%bf%a1%e6%81%af\/2024\/08\/%e7%bb%b4%e5%b0%94%e8%8c%a8%e5%a0%a1%e5%a4%a7%e5%ad%a6jake-l-greenfield%e7%bb%84%e6%8b%9b%e8%81%98%e5%90%af%e4%ba%8b.html","title":{"rendered":"\u7ef4\u5c14\u8328\u5821\u5927\u5b66Jake L.Greenfield\u7ec4\u62db\u8058\u542f\u4e8b"},"content":{"rendered":"
\u4e00\u3001\u8bfe\u9898\u7ec4\u957f\u4ecb\u7ecd<\/strong><\/h4>\n
Jake L. Greenfield<\/strong>\u535a\u58eb\u4e8e2011-2015\u5e74\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u5b8c\u6210\u672c\u79d1\u4e0e\u7855\u58eb\u5b66\u4e60\uff08\u672c\u7855\u5b66\u4e60\uff0c2011-2015\uff0cProf. Milo S. P. Shaffer\uff09\uff0c\u5e76\u5728\u4f50\u6cbb\u4e9a\u7406\u5de5\u5b66\u9662\uff082014\uff0cProf. Christopher W. Jones\uff09\u8fdb\u884c\u4e86\u4e3a\u671f5\u4e2a\u6708\u7684\u5168\u989d\u8d44\u52a9\u7814\u7a76\u3002Jake\u5728\u5251\u6865\u5927\u5b66Prof. Jonathan R. Nitschke\uff08\u5316\u5b66\u535a\u58eb\uff0c2015-2019\uff09\u7684\u6307\u5bfc\u4e0b\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\u30022019\u5e74\u535a\u58eb\u6bd5\u4e1a\u540e\uff0cJake\u56de\u5230\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\uff0c\u5728Matthew J. Fuchter\u6559\u6388\u8bfe\u9898\u7ec4\u505a\u535a\u540e\u7814\u7a76\u30022022\u5e74\uff0cJake\u642c\u5230\u7ef4\u5c14\u8328\u5821\uff08\u5fb7\u56fd\uff09\u4e0eFrank W\u00fcrthner\u6559\u6388\u5408\u4f5c\uff0c\u6700\u521d\u662f\u7531\u6d2a\u5821\u8d44\u52a9\u7684\u535a\u540e\uff0c\u4e0d\u4e45\u4e4b\u540e\uff0c\u57282023\u5e74\uff0cJake\u83b7\u5f97\u4e86\u7531\u5316\u5b66\u5de5\u4e1a\u57fa\u91d1\u4f1a\u8d44\u52a9\u7684Liebig\u5956\u91d1\uff0c\u5f00\u59cb\u4e86\u72ec\u7acb\u7684\u7814\u7a76\u751f\u6daf\uff0c\u540c\u65f6\u6210\u4e3a\u5b66\u9662\u7684Emil Fischer\u7814\u7a76\u5458\u3002<\/p>\n
\u8bfe\u9898\u7ec4\u7f51\u9875\uff1aDr Jake Greenfield – (uni-wuerzburg.de)<\/a><\/p>\n
Dr. Jake L. Greenfield<\/strong> completed his undergraduate studies at Imperial College London (MSci in Chemistry, 2011-2015, under the supervision of Prof. Milo S. P. Shaffer, UK) and carried out a fully funded 5-month research stay at Georgia Institute of Technology (Atlanta, Georgia, USA in 2014, under the supervision of Prof. Christopher W. Jones).Jake conducted his graduate studies at the University of Cambridge, under the supervision of Prof. Jonathan R. Nitschke (PhD in Chemistry, 2015-2019, Cambridge, UK). In 2019, he then returned to Imperial as a Research Associate to work with Prof. Matthew J. Fuchter. In 2022, Jake moved to W\u00fcrzburg (DE) to work with Prof. Frank W\u00fcrthner, initially as a Post-Doc, and then with an Alexander von Humboldt Fellowship. Shortly after this, in 2023, Jake started an independent research career with a Liebig Fellowship, funded by the Fonds der Chemischen Industrie, and is also an Emil-Fischer Fellow of the Faculty.<\/p>\n
\u4e8c\u3001\u8bfe\u9898\u7ec4\u7b80\u4ecb<\/strong><\/h4>\n
Jake\u8bfe\u9898\u7ec4\u4e8e2023\u5e74\u6b63\u5f0f\u6210\u7acb\uff0c\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u5149\u54cd\u5e94\u52a8\u6001\u5171\u4ef7\u5316\u5b66\u3002\u76ee\u524d\uff0cJake\u5c0f\u7ec4\u7684\u524d\u4e24\u7bc7\u8bba\u6587\u5206\u522b\u53d1\u8868\u5728Chem. Sci.<\/em> (
Chem. Sci.<\/em>, 2024,15<\/strong>, 3872\u20133878<\/a>) \u548cJACS<\/em> (J. Am. Chem. Soc.<\/em>, 2024,146<\/strong>, 20720\u201320727<\/a>)\u4e0a\uff0c\u4e3b\u8981\u4e13\u6ce8\u4e8e\u5f00\u53d1\u4e00\u7c7b\u65b0\u578b\u7684\u4e9a\u80fa\u5149\u5f00\u5173\u3002\u81ea20\u4e16\u7eaa50\u5e74\u4ee3\u4ee5\u6765\uff0c\u5149\u5207\u6362\u4e9a\u80fa\u7684\u6784\u5efa\u4e00\u76f4\u4ee5\u6765\u662f\u4e00\u4e2a\u91cd\u5927\u6311\u6218\uff0c\u7279\u522b\u662f\u919b\u4e9a\u80fa\u3002\u7136\u800c\uff0c\u57282024\u5e74\uff0cJake\u5c0f\u7ec4\u53d1\u73b0\u4e86\u4e00\u7c7b\u65b0\u578b\u7684\u5149\u5207\u6362\u4e9a\u80fa\uff0c\u5176\u5728\u53ef\u89c1\u5149\u7167\u5c04\u4e0b\u5b9e\u53ef\u4ee5\u5b9e\u73b0>95%\u7684Z<\/em>-\u5f02\u6784\u4f53\uff0c\u5e76\u4e14\u6781\u5927\u7684\u63d0\u9ad8Z<\/em>-\u5f02\u6784\u4f53\u7684\u534a\u8870\u671f(19.2 h)\u3002\u57fa\u4e8e\u52a8\u6001\u5171\u4ef7\u548c\u5149\u54cd\u5e94\u7279\u6027\u7684\u5149\u5207\u6362\u4e9a\u80fa\uff0c\u5728\u8fde\u7eed\u7167\u5c04\u4e0b\u53ef\u88ab\u8fdb\u4e00\u6b65\u7528\u4e8e\u4ea7\u751f\u201c\u4fe1\u606f\u68d8\u8f6e\u201d\u3002\u76ee\u524d\uff0cJake\u5c0f\u7ec4\u5bf9\u5149\u5207\u6362\u4e9a\u80fa\u7684\u5404\u4e2a\u65b9\u9762\u7684\u7814\u7a76\u8fdb\u884c\u4e86\u63a2\u7d22(\u57fa\u7840\u548c\u5e94\u7528\u8fdb\u884c\u7814\u7a76)\uff0c\u5e76\u4e0e\u5176\u4ed6\u76f8\u5173\u8bfe\u9898\u7ec4\u548c\u884c\u4e1a\u7b49\u5efa\u7acb\u4e86\u8bb8\u591a\u611f\u5174\u8da3\u7684\u5408\u4f5c\u3002<\/p>\n
\u76ee\u524d\uff0cJake\u5c0f\u7ec4\u7684\u56e2\u961f\u9ad8\u5ea6\u56fd\u9645\u5316\uff0c\u6210\u5458\u5206\u522b\u6765\u81ea\u82f1\u56fd\u3001\u4e2d\u56fd\u3001\u5370\u5ea6\u548c\u5fb7\u56fd\u3002\u4ed6\u4eec\u662f\u4e00\u4e2a\u96c4\u5fc3\u52c3\u52c3\u7684\u56e2\u4f53\uff0c\u975e\u5e38\u9002\u5408\u60f3\u8981\u8ffd\u6c42\u5b66\u672f\u751f\u6daf\u7684\u5b66\u751f\u3002Jake\u5c0f\u7ec4\u7684\u5b9e\u9a8c\u5ba4\u4f4d\u4e8e\u5fb7\u56fd\u7ef4\u5c14\u8328\u5821\u5927\u5b66\u6709\u673a\u5316\u5b66\u7814\u7a76\u6240\uff0c\u53ef\u4ee5\u4f7f\u7528\u7ef4\u5c14\u8328\u5821\u201c\u7eb3\u7c73\u7cfb\u7edf\u5316\u5b66\u4e2d\u5fc3\uff08CNC\uff09\u201d\u7684\u6700\u5148\u8fdb\u8bbe\u65bd\u3002\u6b64\u5916\uff0c\u867d\u7136Jake\u7ec4\u662f\u72ec\u7acb\u7684\uff0c\u4f46\u4e0eFrank W\u00fcrthner\u6559\u6388\u7684\u56e2\u961f\u5171\u4eab\u5b9e\u9a8c\u5ba4\u7a7a\u95f4\u548c\u7ec4\u4f1a\uff0c\u4ece\u800c\u5e7f\u6cdb\u63a5\u89e6\u4e0d\u540c\u7c7b\u578b\u7684\u5316\u5b66\u3002<\/p>\n
\u5982\u679c\u60a8\u5bf9\u8be5\u56e2\u961f\u7684\u535a\u58eb\u751f\u751a\u81f3\u535a\u58eb\u540e\u7814\u7a76\u611f\u5174\u8da3\uff0c\u8bf7\u5c3d\u65e9\u901a\u8fc7\u7535\u5b50\u90ae\u4ef6\u8054\u7cfbJake\u6559\u6388(
Jake.Greenfield@uni-wuerzburg.de<\/a>)\u3002\u4f60\u6240\u63d0\u4ea4\u7533\u8bf7\u6750\u6599\u5e94\u8be5\u5305\u62ec\u7b80\u5386\uff0c\u5de5\u4f5c\u603b\u7ed3\uff0c\u4e24\u5c01\u63a8\u8350\u4fe1\u3002\u4f60\u4e5f\u53ef\u4ee5\u5728\u7533\u8bf7\u524d\u901a\u8fc7\u975e\u6b63\u5f0f\u7684\u90ae\u4ef6\u8fdb\u884c\u8054\u7cfb\u3002<\/p>\n
Our research group was officially established in 2023 and have the general interest in photoresponsive dynamic-covalent chemistry. Our group\u2019s first two papers, published inChem. Sci.<\/em> (Chem. Sci.<\/em>, 2024,15<\/strong>, 3872\u20133878) andJACS<\/em> (J. Am. Chem. Soc.<\/em>, 2024,146<\/strong>, 20720\u201320727), focused on exploring a new class of imine-based photoswitches that we discovered, the aryliminopyrazoles. Achieving photoswitchable imines, specifically aldimines, has been a long-standing challenge since the 1950\u2019s. However, in 2024,\u00a0 we discovered a new class of photoswitchable imines that can achieve >95% Z-isomer under visible light irradiation and have a thermal half-life of 19.2 h compared to the previously reported time of less than 1 min at room temperature. These photoswitchable imines, combining dynamic covalent and photoresponsive properties, were further used to generate an \u201cinformation ratchet\u201d under continuous irradiation. Currently, we are working on all aspects of using our photoswitchable imines (fundamentals and applications) and are also interested in establishing collaborations.<\/p>\n
Our team is highly international, with members from the U.K., China, India, and Germany. We are an ambitious group well suited for students who want to pursue an academic career. Our lab is based in the Institute of Organic Chemistry at the University of W\u00fcrzburg, Germany. We have access to the state of the art facilities of the \u201cCenter for Nanosystems Chemistry\u201d here in W\u00fcrzburg. Moreover, while we are independent, we share lab space and group meetings with the group of Prof. Frank W\u00fcrthner, thus giving a broad exposure to different types of chemistry.<\/p>\n
If you are interested in doctoral studies in the group, or even post-doctoral, please get in touch as early as possible. We are interested in candidates who have a high level of motivation, good level of spoken English, and who take pride in their work. Your application should consist of your CV, a cover letter stating two academics who can be contacted to provide a reference letter on your behalf. You can also reach out informally by email.<\/p>\n
Email: \u00a0
Jake.Greenfield@uni-wuerzburg.de<\/a><\/p>\n
\u4ee3\u8868\u6027\u8457\u4f5c\uff1a<\/h4>\n
Publications from the group, other publications can be found on Google Scholar:<\/p>\n

\n
J. Wu, L. Kreimendahl, S. Tao, O. Anhalt and J. L. Greenfield,Chem. Sci.<\/em>,2024<\/strong>, 15, 3872\u20133878.<\/li>\n

J. Wu and J. L. Greenfield,J. Am. <\/em>Chem. Soc.<\/em>,2024<\/strong>, 146, 20720\u201320727.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"\u4e00\u3001\u8bfe\u9898\u7ec4\u957f\u4ecb\u7ecd Jake L. Greenfield\u535a\u58eb\u4e8e2011-2015\u5e74\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u5b8c\u6210\u672c\u79d1\u4e0e\u7855\u58eb\u5b66\u4e60\uff08\u672c\u7855\u5b66\u4e60\uff0c2011-2015\uff0cProf. Milo S. P. Shaffer\uff09\uff0c\u5e76\u5728\u4f50\u6cbb\u4e9a\u7406\u5de5\u5b66\u9662\uff082014\uff0cProf. Christopher W. Jones\uff09\u8fdb\u884c\u4e86\u4e3a\u671f5\u4e2a\u6708\u7684\u5168\u989d\u8d44\u52a9\u7814\u7a76\u3002Jake\u5728\u5251\u6865\u5927\u5b66Prof. Jonathan R. Nitschke\uff08\u5316\u5b66\u535a\u58eb\uff0c2015-2019\uff09\u7684\u6307\u5bfc\u4e0b\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\u30022019\u5e74\u535a\u58eb\u6bd5\u4e1a\u540e\uff0cJake\u56de\u5230\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\uff0c\u5728Matthew J. Fuchter\u6559\u6388\u8bfe\u9898\u7ec4\u505a\u535a\u540e\u7814\u7a76\u30022022\u5e74\uff0cJake\u642c\u5230\u7ef4\u5c14\u8328\u5821\uff08\u5fb7\u56fd\uff09\u4e0eFrank W\u00fcrthner\u6559\u6388\u5408\u4f5c\uff0c\u6700\u521d\u662f\u7531\u6d2a\u5821\u8d44\u52a9\u7684\u535a\u540e\uff0c\u4e0d\u4e45\u4e4b\u540e\uff0c\u57282023\u5e74\uff0cJake\u83b7\u5f97\u4e86\u7531\u5316\u5b66\u5de5\u4e1a\u57fa\u91d1\u4f1a\u8d44\u52a9\u7684Liebig\u5956\u91d1\uff0c\u5f00\u59cb\u4e86\u72ec\u7acb\u7684\u7814\u7a76\u751f\u6daf\uff0c\u540c\u65f6\u6210\u4e3a\u5b66\u9662\u7684Emil Fischer\u7814\u7a76\u5458\u3002 \u8bfe\u9898\u7ec4\u7f51\u9875\uff1aDr Jake Greenfield – (uni-wuerzburg.de) Dr. Jake L. Greenfield completed his undergraduate studies at Imperial College London (MSci in Chemistry, 2011-2015, under the supervision of Prof. Milo S. P. Shaffer, UK) and carried out a fully funded 5-month research stay at Georgia Institute of Technology (Atlanta, Georgia, USA in 2014, under the supervision of Prof. Christopher W. Jones).Jake conducted his graduate studies at the University of Cambridge, under the supervision of Prof. Jonathan R. Nitschke (PhD in Chemistry, 2015-2019, Cambridge, UK). In 2019, he then returned to Imperial as a Research Associate […]","protected":false},"author":26,"featured_media":50991,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2235],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/08\/2382c315a6ba396be1932dd8dafaff52.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-dgq","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50990"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=50990"}],"version-history":[{"count":3,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50990\/revisions"}],"predecessor-version":[{"id":50993,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50990\/revisions\/50993"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/50991"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=50990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=50990"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=50990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":50977,"date":"2024-08-24T06:01:04","date_gmt":"2024-08-23T22:01:04","guid":{"rendered":"\/\/www.gsbet888.com\/?p=50977"},"modified":"2024-08-24T06:01:18","modified_gmt":"2024-08-23T22:01:18","slug":"%e3%80%8cspotlight-research%e3%80%8didpi%e5%82%ac%e5%8c%96%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%a4%9a%e7%83%af%e7%83%83%e7%8e%af%e5%8c%96%e5%88%b6%e5%a4%87%e9%be%99%e6%b6%8e%e9%a6%99","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/interview\/2024\/08\/%e3%80%8cspotlight-research%e3%80%8didpi%e5%82%ac%e5%8c%96%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%a4%9a%e7%83%af%e7%83%83%e7%8e%af%e5%8c%96%e5%88%b6%e5%a4%87%e9%be%99%e6%b6%8e%e9%a6%99.html","title":{"rendered":"\u300cSpotlight Research\u300dIDPi\u50ac\u5316\u4e0d\u5bf9\u79f0\u591a\u70ef\u70c3\u73af\u5316\u5236\u5907\u9f99\u6d8e\u9999"},"content":{"rendered":"
\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n
\u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u5fb7\u56fd\u9a6c\u514b\u601d\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u7684\u7f57\u5a1c\u535a\u58eb\u4e3a\u6211\u4eec\u5206\u4eab\u3002<\/p>\n
2024\u5e747\u670831\u65e5\uff0cNature<\/em><\/strong>\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u5fb7\u56fd\u9a6c\u514b\u601d\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240Benjamin List\u8bfe\u9898\u7ec4\u9898\u4e3a\u300cThe catalytic asymmetric polyenecyclization of homofarnesol to ambrox.\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u4f5c\u8005\u53d1\u73b0\u5728\u6c1f\u4ee3\u6eb6\u5242\u5b58\u5728\u4e0b\uff0c\u7ed3\u5408\u5177\u6709\u5f3aBr\u00f8nsted\u9178\u6027\u548c\u7a7a\u95f4\u53d7\u9650\u7684\u4e9a\u6c28\u57fa\u53cc\u78f7\u9170\u4e9a\u80fa\u916fIDPi\u50ac\u5316\uff0c\u901a\u8fc7\u4e0d\u5bf9\u79f0\u591a\u70ef\u70c3\u73af\u5316\uff0c\u6210\u529f\u4ee5\u826f\u597d\u7684\u4ea7\u7387\u3001\u4f18\u5f02\u7684\u5bf9\u6620\u548c\u975e\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u4e50\uff08-\uff09-\u9f99\u6d8e\u9999\u919a\u548c\u500d\u534a\u841c\u5185\u916f\u5929\u7136\u4ea7\u7269\uff08+\uff09-\u9999\u7d2b\u82cf\u5185\u916f\u3002<\/p>\n

\n
\u201cThe catalytic asymmetric polyenecyclization of homofarnesol to ambrox.<\/p>\n
Na Luo, Mathias Turberg, Markus Leutzsch, Benjamin Mitschke, Sebastian Brunen, Vijay N. Wakchaure, Nils N\u00f6thling, Mathias Schelwies, Ralf Pelzer, Benjamin List*.<\/p>\n
Nature<\/em>\uff0c<\/em>2024<\/strong>, <\/em>632, 795\u2013801. Doi:

10.1038\/s41586-024-07757-7<\/a>.\u201d<\/p>\n<\/blockquote>\n
Q1. <\/strong>\u8bf7\u5bf9<\/strong>\u201cThe catalytic asymmetric polyenecyclization of homofarnesol to ambrox.\u201d<\/strong>\u4f5c<\/strong>\u4e00\u4e2a\u7b80\u5355\u4ecb\u7ecd\u3002<\/strong><\/h4>\n
\u591a\u70ef\u73af\u5316\u53cd\u5e94\u662f\u6307\u5c06\u7b80\u5355\u7684\u975e\u73af\u72b6\u524d\u4f53\u901a\u8fc7\u4e00\u6b65\u53cd\u5e94\u6784\u5efa\u5177\u6709\u591a\u4e2a\u78b3\u78b3\u952e\u4ee5\u53ca\u591a\u4e2a\u7acb\u4f53\u4e2d\u5fc3\u7684\u591a\u73af\u4ea7\u7269\u7684\u53cd\u5e94\u3002\u5728\u6b64\u53cd\u5e94\u4e2d\u540c\u65f6\u5b9e\u73b0\u4ea7\u7269\u5206\u5e03\u548c\u7acb\u4f53\u5316\u5b66\u7684\u7cbe\u786e\u63a7\u5236\u5bf9\u5316\u5b66\u5bb6\u6765\u8bf4\u662f\u4e00\u9879\u8270\u5de8\u7684\u4efb\u52a1\uff0c\u5c24\u5176\u5c06(3E,<\/em>7E<\/em>)-homofarnesol\u901a\u8fc7\u591a\u70ef\u73af\u5316\u8f6c\u5316\u4e3a\u5177\u6709\u9f99\u6d8e\u9999\u5473\u7684(\u2212)-ambrox\u662f\u5316\u5b66\u5408\u6210\u4e2d\u4e00\u76f4\u4ee5\u6765\u7684\u6311\u6218\u3002\u6211\u4eec\u53d1\u73b0\u5728\u6c1f\u4ee3\u6eb6\u5242\u4e2d\uff0c\u7ed3\u5408\u5177\u6709\u5f3aBr\u00f8nsted\u9178\u6027\u548c\u53d7\u9650\u7a7a\u95f4\u7684\u4e9a\u6c28\u57fa\u53cc\u78f7\u9170\u4e9a\u80fa\u916fIDPi\u4f5c\u4e3a\u50ac\u5316\u5242\u80fd\u591f\u4ee5\u826f\u597d\u7684\u4ea7\u7387\u4ee5\u53ca\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3001\u975e\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff08-\uff09-\u9f99\u6d8e\u9999\u919a\u548c\u500d\u534a\u841c\u5185\u916f\u5929\u7136\u4ea7\u7269\uff08+\uff09-\u9999\u7d2b\u82cf\u5185\u916f\u3002\u5b9e\u9a8c\u8868\u660e\u8be5\u53cd\u5e94\u4e3b\u8981\u901a\u8fc7\u534f\u540c\u9014\u5f84\u8fdb\u884c\uff0c\u7b26\u5408Stork-Eschenmoser\u5047\u8bbe\u3002IDPi\u50ac\u5316\u5242\u7684\u5fae\u578b\u7a7a\u8154\u73af\u5883\u5bf9\u5b9e\u73b0\u53cd\u5e94\u7684\u9009\u62e9\u6027\u975e\u5e38\u91cd\u8981\uff0c\u800c\u8fd9\u5728\u6b64\u4e4b\u524d\u53ea\u6709\u9176\u50ac\u5316\u80fd\u5b9e\u73b0\u8fd9\u79cd\u9ad8\u9009\u62e9\u6027\u3002<\/p>\n
Q2.<\/strong>\u5728\u7814\u7a76\u7684\u65f6\u5019\u9047\u5230\u8fc7\u600e\u6837\u7684\u56f0\u96be\u5462\uff1f\u53c8\u662f\u600e\u6837\u514b\u670d\u7684\u5462\uff1f<\/strong><\/h4>\n
\u672c\u90e8\u5206\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u5728\u7b5b\u9009\u50ac\u5316\u53cd\u5e94\u6761\u4ef6\u8c03\u63a7\u533a\u57df\u9009\u62e9\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4ed8\u51fa\u4e86\u8270\u8f9b\u7684\u5de5\u4f5c\uff0c\u66fe\u5c1d\u8bd5\u4e86\u65e0\u6570\u79cd\u6761\u4ef6\u4e0e\u8bd5\u5242\u3002\u5728\u6b64\u671f\u95f4\u6211\u66fe\u6570\u6b21\u6000\u7591\u81ea\u5df1\uff0c\u7ecf\u5386\u591a\u6b21\u5931\u8d25\u4f7f\u81ea\u5df1\u60c5\u7eea\u4f4e\u843d\u3002\u7814\u7a76\u5de5\u4f5c\u4e5f\u4e00\u5ea6\u8fdb\u5c55\u7f13\u6162\uff0c\u4f46\u6b63\u662f\u8fd9\u65f6\u6765\u81ea\u7537\u670b\u53cb\u548c\u5bb6\u4eba\u7684\u9f13\u52b1\u548c\u652f\u6301\u8ba9\u6211\u53ca\u65f6\u8c03\u6574\u4e86\u72b6\u6001\uff0c\u6700\u7ec8\u4e5f\u662f\u9010\u6e10\u5c1d\u8bd5\u51fa\u542b\u6c1f\u70f7\u70c3\u4f5c\u4e3a\u5173\u952e\u8bd5\u5242\uff0c\u987a\u5229\u83b7\u5f97\u4e86\u7406\u60f3\u7684\u53cd\u5e94\u7ed3\u679c\u3002<\/p>\n
Q3. <\/strong>\u672c\u6b21\u7814\u7a76\u4e3b\u4f53\uff0c\u6709\u6ca1\u6709\u4ec0\u4e48\u8ba9\u60a8\u611f\u89c9\u7279\u522b\u8f9b\u82e6\u548c\u70e7\u8111\u5462\uff1f<\/strong><\/h4>\n
\u6709\u673a\u5408\u6210\u4f5c\u4e3a\u5b9e\u9a8c\u5b66\u79d1\uff0c\u5728\u7814\u7a76\u5de5\u4f5c\u4e2d\u4e0d\u4ec5\u5f97\u7ecf\u5e38\u9762\u5bf9\u7e41\u6742\u7684\u5b9e\u9a8c\u5de5\u4f5c\uff0c\u4e5f\u5f97\u5728\u4f17\u591a\u6d4b\u8bd5\u6570\u636e\u4e2d\u5206\u6790\u5f52\u7eb3\u51fa\u6709\u610f\u4e49\u7684\u7ed3\u8bba\u3002\u5728\u6211\u7684\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u7ecf\u5e38\u6d89\u53ca\u53cd\u5e94\u7269\u5b58\u5728\u591a\u4e2a\u53cd\u5e94\u4f4d\u70b9\u4e0e\u624b\u6027\u4e2d\u5fc3\u7684\u60c5\u51b5\uff0c\u5bfc\u81f4\u4ea7\u7269\u53ef\u80fd\u5b58\u5728\u6570\u5341\u4e2a\u5f02\u6784\u4f53\uff0c\u7ecf\u5e38\u4e3a\u4e86\u786e\u8ba4\u5f02\u6784\u4f53\u7684\u7ed3\u6784\u82b1\u8d39\u5927\u91cf\u7684\u65f6\u95f4\u3002\u540c\u65f6\u4e5f\u5f97\u8fdb\u4e00\u6b65\u5408\u6210\u4e0d\u540c\u6027\u80fd\u7684\u50ac\u5316\u5242\u8c03\u63a7\u53cd\u5e94\u7684\u9009\u62e9\u6027\u3002\u6700\u7ec8\u5f97\u5230\u53cd\u5e94\u7ed3\u679c\u540e\u4ecd\u7136\u9700\u8981\u5229\u7528\u5305\u62ec\u7406\u8bba\u8ba1\u7b97\u5728\u5185\u7684\u5404\u79cd\u624b\u6bb5\u8fdb\u884c\u53cd\u5e94\u673a\u7406\u9a8c\u8bc1\u3002\u5728\u4ee5\u4e0a\u6574\u4e2a\u8fc7\u7a0b\u4e2d\u4e0d\u4ec5\u9700\u8981\u5145\u8db3\u7684\u63a2\u7a76\u7cbe\u795e\uff0c\u4e5f\u9700\u8981\u5bf9\u5408\u6210\u7b56\u7565\u3001\u7269\u7406\u6709\u673a\u4ee5\u53ca\u4eea\u5668\u79d1\u5b66\u7b49\u65b9\u9762\u7684\u5b66\u79d1\u77e5\u8bc6\u66f4\u4e3a\u6df1\u539a\u7684\u7406\u89e3\uff0c\u8fd9\u4e5f\u662f\u76ee\u524d\u6211\u4ecd\u9700\u8981\u52a0\u5f3a\u7684\u65b9\u5411\u3002<\/p>\n
Q4. <\/strong>\u5c06\u6765\u60f3\u7ee7\u7eed\u7814\u7a76\u5316\u5b66\u7684\u54ea\u4e2a\u65b9\u5411\u5462\uff1f<\/strong><\/h4>\n
\u76ee\u524d\u6211\u4e3b\u8981\u4ece\u4e8b\u50ac\u5316\u4e0d\u5bf9\u79f0\u5408\u6210\u5de5\u4f5c\uff0c\u672a\u6765\u6211\u60f3\u62d3\u5c55\u51fa\u66f4\u591a\u65b0\u7b56\u7565\u3001\u65b0\u53cd\u5e94\uff0c\u5e76\u4e14\u529b\u6c42\u5f00\u53d1\u51fa\u6709\u8db3\u591f\u6f5c\u529b\u5e94\u7528\u4e8e\u5de5\u4e1a\u5c4a\u7684\u521b\u65b0\u5408\u6210\u65b9\u6cd5\u4e0e\u65b0\u9896\u7ed3\u6784<\/p>\n
Q5. <\/strong>\u6700\u540e\uff0c\u6709\u4ec0\u4e48\u60f3\u5bf9\u5404\u4f4d\u8bfb\u8005\u8bf4\u7684\u5417\uff1f<\/strong><\/h4>\n
\u9009\u62e9\u505a\u79d1\u5b66\u7814\u7a76\u6ce8\u5b9a\u4e0d\u662f\u4e00\u6761\u5bb9\u6613\u7684\u8def\uff0c\u52bf\u5fc5\u4f1a\u7ecf\u5386\u65e0\u6570\u574e\u5777\u4e0e\u632b\u6298\u3002\u4f46\u662f\u8bf7\u76f8\u4fe1\uff0c\u53ea\u8981\u80af\u575a\u6301\u81ea\u5df1\u7684\u7406\u60f3\uff0c\u4e00\u5f80\u65e0\u524d\u5730\u6295\u5165\u5230\u81ea\u5df1\u7684\u4e8b\u4e1a\u4e2d\uff0c\u4e00\u5b9a\u53ef\u4ee5\u505a\u51fa\u4e00\u756a\u6210\u5c31\uff01<\/p>\n
\u4f5c\u8005\u6559\u80b2\u80cc\u666f\u7b80\u4ecb<\/strong><\/h4>\n
<\/strong><\/p>\n
\u6559\u80b2\u80cc\u666f\uff1a<\/strong><\/h4>\n
2012-2016\u00a0 \u6e58\u6f6d\u5927\u5b66\u00a0 \u9ad8\u5206\u5b50\u6750\u6599\u4e0e\u5de5\u7a0b\u4e13\u4e1a\u00a0 \u5b66\u58eb\u5b66\u4f4d<\/p>\n
2016-2021\u00a0 \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240\u00a0 \u6709\u673a\u5316\u5b66\u4e13\u4e1a\u00a0 \u535a\u58eb\u5b66\u4f4d\u00a0 \u5bfc\u5e08\uff1a \u738b\u5176\u5f3a \u7814\u7a76\u5458<\/p>\n
2022-\u81f3\u4eca\u00a0 \u9a6c\u514b\u601d\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u00a0 \u535a\u58eb\u540e \u5408\u4f5c\u5bfc\u5e08\uff1a Prof. Benjamin List<\/p>\n
\u83b7\u5956\u7ecf\u5386\uff1a<\/strong><\/h4>\n
\u6e56\u5357\u7701\u4f18\u79c0\u6bd5\u4e1a\u751f<\/p>\n
\u535a\u58eb\u751f\u56fd\u5bb6\u5956\u5b66\u91d1<\/p>\n
\u5317\u4eac\u5e02\u4f18\u79c0\u6bd5\u4e1a\u751f<\/p>\n
2024\u5e74\u83b7\u5f97\u6d2a\u5821\u57fa\u91d1\u4f1a\u8d44\u52a9<\/p>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u5fb7\u56fd\u9a6c\u514b\u601d\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u7684\u7f57\u5a1c\u535a\u58eb\u4e3a\u6211\u4eec\u5206\u4eab\u3002 2024\u5e747\u670831\u65e5\uff0cNature\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u5fb7\u56fd\u9a6c\u514b\u601d\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240Benjamin List\u8bfe\u9898\u7ec4\u9898\u4e3a\u300cThe catalytic asymmetric polyenecyclization of homofarnesol to ambrox.\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u4f5c\u8005\u53d1\u73b0\u5728\u6c1f\u4ee3\u6eb6\u5242\u5b58\u5728\u4e0b\uff0c\u7ed3\u5408\u5177\u6709\u5f3aBr\u00f8nsted\u9178\u6027\u548c\u7a7a\u95f4\u53d7\u9650\u7684\u4e9a\u6c28\u57fa\u53cc\u78f7\u9170\u4e9a\u80fa\u916fIDPi\u50ac\u5316\uff0c\u901a\u8fc7\u4e0d\u5bf9\u79f0\u591a\u70ef\u70c3\u73af\u5316\uff0c\u6210\u529f\u4ee5\u826f\u597d\u7684\u4ea7\u7387\u3001\u4f18\u5f02\u7684\u5bf9\u6620\u548c\u975e\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\u4e50\uff08-\uff09-\u9f99\u6d8e\u9999\u919a\u548c\u500d\u534a\u841c\u5185\u916f\u5929\u7136\u4ea7\u7269\uff08+\uff09-\u9999\u7d2b\u82cf\u5185\u916f\u3002 \u201cThe catalytic asymmetric polyenecyclization of homofarnesol to ambrox. Na Luo, Mathias Turberg, Markus Leutzsch, Benjamin Mitschke, Sebastian Brunen, Vijay N. Wakchaure, Nils N\u00f6thling, Mathias Schelwies, Ralf Pelzer, Benjamin List*. Nature\uff0c2024, 632, 795\u2013801. Doi: 10.1038\/s41586-024-07757-7.\u201d Q1. \u8bf7\u5bf9\u201cThe catalytic asymmetric polyenecyclization of homofarnesol to ambrox.\u201d\u4f5c\u4e00\u4e2a\u7b80\u5355\u4ecb\u7ecd\u3002 \u591a\u70ef\u73af\u5316\u53cd\u5e94\u662f\u6307\u5c06\u7b80\u5355\u7684\u975e\u73af\u72b6\u524d\u4f53\u901a\u8fc7\u4e00\u6b65\u53cd\u5e94\u6784\u5efa\u5177\u6709\u591a\u4e2a\u78b3\u78b3\u952e\u4ee5\u53ca\u591a\u4e2a\u7acb\u4f53\u4e2d\u5fc3\u7684\u591a\u73af\u4ea7\u7269\u7684\u53cd\u5e94\u3002\u5728\u6b64\u53cd\u5e94\u4e2d\u540c\u65f6\u5b9e\u73b0\u4ea7\u7269\u5206\u5e03\u548c\u7acb\u4f53\u5316\u5b66\u7684\u7cbe\u786e\u63a7\u5236\u5bf9\u5316\u5b66\u5bb6\u6765\u8bf4\u662f\u4e00\u9879\u8270\u5de8\u7684\u4efb\u52a1\uff0c\u5c24\u5176\u5c06(3E,7E)-homofarnesol\u901a\u8fc7\u591a\u70ef\u73af\u5316\u8f6c\u5316\u4e3a\u5177\u6709\u9f99\u6d8e\u9999\u5473\u7684(\u2212)-ambrox\u662f\u5316\u5b66\u5408\u6210\u4e2d\u4e00\u76f4\u4ee5\u6765\u7684\u6311\u6218\u3002\u6211\u4eec\u53d1\u73b0\u5728\u6c1f\u4ee3\u6eb6\u5242\u4e2d\uff0c\u7ed3\u5408\u5177\u6709\u5f3aBr\u00f8nsted\u9178\u6027\u548c\u53d7\u9650\u7a7a\u95f4\u7684\u4e9a\u6c28\u57fa\u53cc\u78f7\u9170\u4e9a\u80fa\u916fIDPi\u4f5c\u4e3a\u50ac\u5316\u5242\u80fd\u591f\u4ee5\u826f\u597d\u7684\u4ea7\u7387\u4ee5\u53ca\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3001\u975e\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210\uff08-\uff09-\u9f99\u6d8e\u9999\u919a\u548c\u500d\u534a\u841c\u5185\u916f\u5929\u7136\u4ea7\u7269\uff08+\uff09-\u9999\u7d2b\u82cf\u5185\u916f\u3002\u5b9e\u9a8c\u8868\u660e\u8be5\u53cd\u5e94\u4e3b\u8981\u901a\u8fc7\u534f\u540c\u9014\u5f84\u8fdb\u884c\uff0c\u7b26\u5408Stork-Eschenmoser\u5047\u8bbe\u3002IDPi\u50ac\u5316\u5242\u7684\u5fae\u578b\u7a7a\u8154\u73af\u5883\u5bf9\u5b9e\u73b0\u53cd\u5e94\u7684\u9009\u62e9\u6027\u975e\u5e38\u91cd\u8981\uff0c\u800c\u8fd9\u5728\u6b64\u4e4b\u524d\u53ea\u6709\u9176\u50ac\u5316\u80fd\u5b9e\u73b0\u8fd9\u79cd\u9ad8\u9009\u62e9\u6027\u3002 Q2.\u5728\u7814\u7a76\u7684\u65f6\u5019\u9047\u5230\u8fc7\u600e\u6837\u7684\u56f0\u96be\u5462\uff1f\u53c8\u662f\u600e\u6837\u514b\u670d\u7684\u5462\uff1f \u672c\u90e8\u5206\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u5728\u7b5b\u9009\u50ac\u5316\u53cd\u5e94\u6761\u4ef6\u8c03\u63a7\u533a\u57df\u9009\u62e9\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4ed8\u51fa\u4e86\u8270\u8f9b\u7684\u5de5\u4f5c\uff0c\u66fe\u5c1d\u8bd5\u4e86\u65e0\u6570\u79cd\u6761\u4ef6\u4e0e\u8bd5\u5242\u3002\u5728\u6b64\u671f\u95f4\u6211\u66fe\u6570\u6b21\u6000\u7591\u81ea\u5df1\uff0c\u7ecf\u5386\u591a\u6b21\u5931\u8d25\u4f7f\u81ea\u5df1\u60c5\u7eea\u4f4e\u843d\u3002\u7814\u7a76\u5de5\u4f5c\u4e5f\u4e00\u5ea6\u8fdb\u5c55\u7f13\u6162\uff0c\u4f46\u6b63\u662f\u8fd9\u65f6\u6765\u81ea\u7537\u670b\u53cb\u548c\u5bb6\u4eba\u7684\u9f13\u52b1\u548c\u652f\u6301\u8ba9\u6211\u53ca\u65f6\u8c03\u6574\u4e86\u72b6\u6001\uff0c\u6700\u7ec8\u4e5f\u662f\u9010\u6e10\u5c1d\u8bd5\u51fa\u542b\u6c1f\u70f7\u70c3\u4f5c\u4e3a\u5173\u952e\u8bd5\u5242\uff0c\u987a\u5229\u83b7\u5f97\u4e86\u7406\u60f3\u7684\u53cd\u5e94\u7ed3\u679c\u3002 Q3. \u672c\u6b21\u7814\u7a76\u4e3b\u4f53\uff0c\u6709\u6ca1\u6709\u4ec0\u4e48\u8ba9\u60a8\u611f\u89c9\u7279\u522b\u8f9b\u82e6\u548c\u70e7\u8111\u5462\uff1f \u6709\u673a\u5408\u6210\u4f5c\u4e3a\u5b9e\u9a8c\u5b66\u79d1\uff0c\u5728\u7814\u7a76\u5de5\u4f5c\u4e2d\u4e0d\u4ec5\u5f97\u7ecf\u5e38\u9762\u5bf9\u7e41\u6742\u7684\u5b9e\u9a8c\u5de5\u4f5c\uff0c\u4e5f\u5f97\u5728\u4f17\u591a\u6d4b\u8bd5\u6570\u636e\u4e2d\u5206\u6790\u5f52\u7eb3\u51fa\u6709\u610f\u4e49\u7684\u7ed3\u8bba\u3002\u5728\u6211\u7684\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u7ecf\u5e38\u6d89\u53ca\u53cd\u5e94\u7269\u5b58\u5728\u591a\u4e2a\u53cd\u5e94\u4f4d\u70b9\u4e0e\u624b\u6027\u4e2d\u5fc3\u7684\u60c5\u51b5\uff0c\u5bfc\u81f4\u4ea7\u7269\u53ef\u80fd\u5b58\u5728\u6570\u5341\u4e2a\u5f02\u6784\u4f53\uff0c\u7ecf\u5e38\u4e3a\u4e86\u786e\u8ba4\u5f02\u6784\u4f53\u7684\u7ed3\u6784\u82b1\u8d39\u5927\u91cf\u7684\u65f6\u95f4\u3002\u540c\u65f6\u4e5f\u5f97\u8fdb\u4e00\u6b65\u5408\u6210\u4e0d\u540c\u6027\u80fd\u7684\u50ac\u5316\u5242\u8c03\u63a7\u53cd\u5e94\u7684\u9009\u62e9\u6027\u3002\u6700\u7ec8\u5f97\u5230\u53cd\u5e94\u7ed3\u679c\u540e\u4ecd\u7136\u9700\u8981\u5229\u7528\u5305\u62ec\u7406\u8bba\u8ba1\u7b97\u5728\u5185\u7684\u5404\u79cd\u624b\u6bb5\u8fdb\u884c\u53cd\u5e94\u673a\u7406\u9a8c\u8bc1\u3002\u5728\u4ee5\u4e0a\u6574\u4e2a\u8fc7\u7a0b\u4e2d\u4e0d\u4ec5\u9700\u8981\u5145\u8db3\u7684\u63a2\u7a76\u7cbe\u795e\uff0c\u4e5f\u9700\u8981\u5bf9\u5408\u6210\u7b56\u7565\u3001\u7269\u7406\u6709\u673a\u4ee5\u53ca\u4eea\u5668\u79d1\u5b66\u7b49\u65b9\u9762\u7684\u5b66\u79d1\u77e5\u8bc6\u66f4\u4e3a\u6df1\u539a\u7684\u7406\u89e3\uff0c\u8fd9\u4e5f\u662f\u76ee\u524d\u6211\u4ecd\u9700\u8981\u52a0\u5f3a\u7684\u65b9\u5411\u3002 Q4. \u5c06\u6765\u60f3\u7ee7\u7eed\u7814\u7a76\u5316\u5b66\u7684\u54ea\u4e2a\u65b9\u5411\u5462\uff1f \u76ee\u524d\u6211\u4e3b\u8981\u4ece\u4e8b\u50ac\u5316\u4e0d\u5bf9\u79f0\u5408\u6210\u5de5\u4f5c\uff0c\u672a\u6765\u6211\u60f3\u62d3\u5c55\u51fa\u66f4\u591a\u65b0\u7b56\u7565\u3001\u65b0\u53cd\u5e94\uff0c\u5e76\u4e14\u529b\u6c42\u5f00\u53d1\u51fa\u6709\u8db3\u591f\u6f5c\u529b\u5e94\u7528\u4e8e\u5de5\u4e1a\u5c4a\u7684\u521b\u65b0\u5408\u6210\u65b9\u6cd5\u4e0e\u65b0\u9896\u7ed3\u6784 Q5. \u6700\u540e\uff0c\u6709\u4ec0\u4e48\u60f3\u5bf9\u5404\u4f4d\u8bfb\u8005\u8bf4\u7684\u5417\uff1f \u9009\u62e9\u505a\u79d1\u5b66\u7814\u7a76\u6ce8\u5b9a\u4e0d\u662f\u4e00\u6761\u5bb9\u6613\u7684\u8def\uff0c\u52bf\u5fc5\u4f1a\u7ecf\u5386\u65e0\u6570\u574e\u5777\u4e0e\u632b\u6298\u3002\u4f46\u662f\u8bf7\u76f8\u4fe1\uff0c\u53ea\u8981\u80af\u575a\u6301\u81ea\u5df1\u7684\u7406\u60f3\uff0c\u4e00\u5f80\u65e0\u524d\u5730\u6295\u5165\u5230\u81ea\u5df1\u7684\u4e8b\u4e1a\u4e2d\uff0c\u4e00\u5b9a\u53ef\u4ee5\u505a\u51fa\u4e00\u756a\u6210\u5c31\uff01 \u4f5c\u8005\u6559\u80b2\u80cc\u666f\u7b80\u4ecb \u6559\u80b2\u80cc\u666f\uff1a 2012-2016\u00a0 \u6e58\u6f6d\u5927\u5b66\u00a0 \u9ad8\u5206\u5b50\u6750\u6599\u4e0e\u5de5\u7a0b\u4e13\u4e1a\u00a0 \u5b66\u58eb\u5b66\u4f4d 2016-2021\u00a0 \u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240\u00a0 \u6709\u673a\u5316\u5b66\u4e13\u4e1a\u00a0 \u535a\u58eb\u5b66\u4f4d\u00a0 \u5bfc\u5e08\uff1a \u738b\u5176\u5f3a \u7814\u7a76\u5458 2022-\u81f3\u4eca\u00a0 \u9a6c\u514b\u601d\u666e\u6717\u514b\u7164\u70ad\u7814\u7a76\u6240\u00a0 \u535a\u58eb\u540e \u5408\u4f5c\u5bfc\u5e08\uff1a Prof. Benjamin List \u83b7\u5956\u7ecf\u5386\uff1a \u6e56\u5357\u7701\u4f18\u79c0\u6bd5\u4e1a\u751f \u535a\u58eb\u751f\u56fd\u5bb6\u5956\u5b66\u91d1 \u5317\u4eac\u5e02\u4f18\u79c0\u6bd5\u4e1a\u751f 2024\u5e74\u83b7\u5f97\u6d2a\u5821\u57fa\u91d1\u4f1a\u8d44\u52a9 \u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c 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\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/strong><\/p>\n
\u5bfc\u8bfb\uff1a<\/strong><\/h4>\n
\u8fd1\u671f\uff0c\u6d59\u6c5f\u5e08\u8303\u5927\u5b66\u7684\u5f20\u5ca9\u8bfe\u9898\u7ec4\u5728Org. Chem. Front.<\/em><\/strong>\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u5229\u7528\u5149\u8bf1\u5bfcC-C\u6d3b\u5316\u548c\u5e94\u53d8\u5f20\u529b\u91ca\u653e\u7684\u7b56\u7565\uff0c\u5b9e\u73b0\u4e86\u73af\u5916\u78b3\u81ea\u7531\u57fa\u5f62\u6210\u5f15\u53d1\u73af\u4e01\u70f7\u5f00\u73af\u5408\u6210\u03b3\uff0c\u03b4-\u4e0d\u9971\u548c\u916e\u3002<\/p>\n

\n
\u201cPhotoredox-enabled ring-opening of cyclobutanes via the formation of a carbon radical.<\/p>\n
Chunhang Zhao, Wenjing Ma, Kairui Liu, Ruoyang Xu, Xiuya Ma and Yan Zhang *.<\/p>\n
Org. Chem. Front.,<\/em>2024,<\/strong>11, 4663-4670. Doi: DOI:

10.1039\/D4QO00996G<\/a><\/p>\n<\/blockquote>\n
<\/p>\n
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\uff08\u975e\u5e38\u611f\u8c22\u5f20\u5ca9\u6559\u6388\u5bf9<\/strong>Chem-Station<\/em><\/strong>\u7684\u652f\u6301<\/strong>\uff09<\/p>\n
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\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n
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4.\u539f\u5219\u4e0a\u5e74\u9f8435\u5468\u5c81\u4ee5\u4e0b\u3002<\/p>\n
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\n
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4.\u2002\u9879\u76ee\u652f\u6301\uff1a\u53ef\u7533\u8bf7\u56fd\u5bb6\u7ea7\u535a\u58eb\u540e\u9879\u76ee\u3001\u9662\u7ea7\u201c\u7279\u522b\u7814\u7a76\u52a9\u7406\u8d44\u52a9\u9879\u76ee\u201d\uff0c\u652f\u6301\u7533\u62a5\u4e91\u5357\u7701\u201c\u5174\u6ec7\u82f1\u624d\u652f\u6301\u8ba1\u5212\u201d \uff08\u7701\u5916\u4e2a\u4eba\u8865\u8d3450\u4e07\uff0c\u7701\u5185\u4e2a\u4eba\u8865\u8d3425\u4e07\uff1b\u6700\u9ad8100\u4e07\u9879\u76ee\u652f\u6301\u7ecf\u8d39\uff09\u201c\u5f69\u4e91\u535a\u58eb\u540e\u8ba1\u5212\u201d\u7b49\u76f8\u5173\u9879\u76ee\uff1b<\/p>\n
5.\u2002\u540e\u7eed\u652f\u6301\uff1a\u8058\u671f\u7ed3\u675f\u540e\u901a\u8fc7\u8003\u6838\u8005\u6709\u8d44\u683c\u7533\u62a5\u6211\u6240\u4e8b\u4e1a\u7f16\u5236\u5c97\u4f4d\u8058\u7528\uff0c\u7279\u522b\u4f18\u79c0\u8005\u53ef\u7533\u8bf7\u4e2d\u56fd\u79d1\u5b66\u9662\u4eba\u624d\u652f\u6301\u8ba1\u5212\u9879\u76ee\u6216\u6309\u7167\u7814\u7a76\u6240\u201c\u4f18\u79c0\u4eba\u624d\u201d\uff08\u526f\u7814\u7a76\u5458\uff09\u5c42\u6b21\u5f15\u8fdb\u3002<\/p>\n

\n
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\u3010\u62db\u8058\u7a0b\u5e8f\u3011<\/strong><\/h4>\n
1.\u62a5\u540d\u622a\u6b62\u65f6\u95f4\uff1a\u62db\u5230\u5408\u9002\u4eba\u9009\u4e3a\u6b62\u3002<\/p>\n
2.\u5c06\u2460\u4e2a\u4eba\u7b80\u5386\uff0c\u2461\u672c\u4eba\u5b66\u5386\u5b66\u4f4d\u7535\u5b50\u7248\u6750\u6599\uff0c\u2462\u672c\u4eba\u79d1\u7814\u6210\u679c\u60c5\u51b5\uff0c\u4ee5\u7535\u5b50\u90ae\u4ef6\u65b9\u5f0f\u53d1\u9001\u81f3\u8054\u7cfb\u4eba\u90ae\u7bb1\u3002<\/p>\n
3.\u2002\u8d44\u683c\u5ba1\u67e5\uff1a\u6839\u636e\u5e94\u8058\u8005\u63d0\u4f9b\u5c65\u5386\u6750\u6599\u548c\u5e94\u8058\u5c97\u4f4d\u8981\u6c42\uff0c\u5bf9\u5e94\u8058\u8005\u8fdb\u884c\u8d44\u683c\u5ba1\u67e5\uff0c\u8d44\u683c\u5ba1\u67e5\u901a\u8fc7\u8005\uff0c\u901a\u77e5\u53c2\u52a0\u9762\u8bd5\u53ca\u7b54\u8fa9\u3002\u672a\u901a\u8fc7\u8d44\u683c\u5ba1\u67e5\u8005\u4e0d\u53e6\u884c\u901a\u77e5\u3002<\/p>\n
\u3010\u8054\u7cfb\u65b9\u5f0f\u3011<\/strong><\/h4>\n
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\u5c97\u4f4d1-2\u8054\u7cfb\u4eba\uff1a\u9648\u8001\u5e08\uff0c\u8054\u7cfb\u65b9\u5f0f\uff1a\u00a0\u00a0

chenduozhi@mail.kib.ac.cn<\/a><\/p>\n
\u5c97\u4f4d3\u8054\u7cfb\u4eba\uff1a\u66f9\u8001\u5e08\uff0c\u8054\u7cfb\u65b9\u5f0f\uff1a\u00a0\u00a0\u00a0\u00a0\u00a0
caomingming@mail.kib.ac.cn<\/a><\/p>\n
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\u90ae\u653f\u7f16\u7801\uff1a650201<\/p>\n","protected":false},"excerpt":{"rendered":"\u2002\u2002\u4e2d\u56fd\u79d1\u5b66\u9662\u6606\u660e\u690d\u7269\u6240\u90dd\u5c0f\u6c5f\u9662\u58eb\u56e2\u961f\uff0c\u4e3b\u8981\u4ece\u4e8b\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u53d1\u73b0\u3001\u5929\u7136\u4ea7\u7269\u5316\u5b66\u751f\u7269\u5b66\u3001\u65b0\u578b\u519c\u836f\u3001\u5929\u7136\u836f\u7269\u5f00\u53d1\u3001\u5929\u7136\u4ea7\u7269\u751f\u7269\u5408\u6210\u3001\u836f\u7406\u5b66\u7b49\u7814\u7a76\u3002\u56e0\u7814\u7a76\u56e2\u961f\u53d1\u5c55\u9700\u8981\uff0c\u73b0\u516c\u5f00\u62db\u8058\u535a\u58eb\u540e\u7814\u7a76\u4eba\u54582-3\u540d\u3002\u5177\u4f53\u62db\u8058\u4fe1\u606f\u5982\u4e0b\uff1a \u3010\u62db\u8058\u5c97\u4f4d\u3011 \u535a\u58eb\u540e \uff08\u7279\u522b\u7814\u7a76\u52a9\u7406\uff092-3\u540d\uff0c\uff08\u51fa\u7ad9\u540e\uff0c\u8868\u73b0\u4f18\u5f02\u8005\u53ef\u8058\u4e3a\u52a9\u7406\u7814\u7a76\u5458\u6216\u526f\u7814\u7a76\u5458\uff09 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\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n
\u5bfc\u8bfb\uff1a<\/h4>\n
\u8fd1\u671f\uff0c\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684Hirohisa Ohmiya\u4e0eKazunori Nagao\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.<\/em>\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u53cc\u91cd\u94b4\/\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u8102\u80aa\u65cf\u70ef\u70c3\u4e0ecollidine\u00b7HX\u76d0\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684\u70f7\u57fa\u5364\u5206\u5b50\u7684\u6784\u5efa\u3002<\/p>\n

\n
A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes<\/p>\n
S. Shibutani, K. Nagao, H. Ohmiya,J. Am. Chem. Soc.<\/em>2024<\/strong>,146<\/em>, 4375. doi:

10.1021\/jacs.3c10133<\/a><\/p>\n<\/blockquote>\n
<\/a><\/p>\n
\u6b63\u6587\uff1a<\/h4>\n
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\u6b64\u5916\uff0c\u5bf9\u4e8eC\u2212X\u952e\u7684\u5f62\u6210\u53ef\u80fd\u5b58\u5728\u4e24\u79cd\u53ef\u80fd\u7684\u673a\u7406\uff0c\u5373\u70f7\u57fa\u81ea\u7531\u57fa\u6216\u70f7\u57fa\u94b4(III)\u4e0e\u5364\u5316\u94b4(III)\u7684S_{H<\/sub>2\u53cd\u5e94 (Scheme 1B)\u4ee5\u53ca\u5364\u5316\u7269\u9634\u79bb\u5b50\u4e0e\u70f7\u57fa\u94b4(IV)\u914d\u5408\u7269\u4e4b\u95f4\u7684S_{N<\/sub>2\u53cd\u5e94\u3002\u4e3a\u4e86\u533a\u5206\u4e0a\u8ff0\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u6c22\u5364\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Figure 2)\u3002\u603b\u7ed3\uff1a<\/p>\n}}
\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684Hirohisa Ohmiya\u4e0eKazunori Nagao\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u53cc\u91cd\u94b4\/\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u8102\u80aa\u65cf\u70ef\u70c3\u4e0ecollidine\u00b7HX\u76d0\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684\u70f7\u57fa\u5364\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u6c22\u5364\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u539f\u5b50\u7ecf\u6d4e\u6027\u7b49\u4f18\u52bf\u3002<\/p>\n
\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n
\n
[1] S. W. M. Crossley, C. Obradors, R. M. Martinez, R. A. Shenvi,Chem. Rev. <\/em>2016<\/strong>,116<\/em>, 8912. doi:

10.1021\/acs.chemrev.6b00334<\/a>.<\/li>\n
[2] D. J. Wilger, J. M. M. Grandjean, T. R. Lammert, D. A. Nicewicz,Nat. Chem. <\/em>2014<\/strong>,6<\/em>, 720. doi:
10.1038\/nchem.2000<\/a>.<\/li>\n
[3] J. Kim, X. Sun, B. A. van der Worp, T. Ritter,Nat. Catal. <\/em>2023<\/strong>,6<\/em>, 196. doi:
10.1038\/s41929-023-00914-7<\/a>.<\/li>\n<\/ul>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u6749\u6749 \u5bfc\u8bfb\uff1a \u8fd1\u671f\uff0c\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684Hirohisa Ohmiya\u4e0eKazunori Nagao\u8bfe\u9898\u7ec4\u5728J. Am. Chem. Soc.\u4e2d\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u53cc\u91cd\u94b4\/\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u8102\u80aa\u65cf\u70ef\u70c3\u4e0ecollidine\u00b7HX\u76d0\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684\u70f7\u57fa\u5364\u5206\u5b50\u7684\u6784\u5efa\u3002 A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes S. Shibutani, K. Nagao, H. Ohmiya, J. Am. Chem. Soc. 2024, 146, 4375. doi: 10.1021\/jacs.3c10133 \u6b63\u6587\uff1a \u70f7\u57fa\u5364\u9aa8\u67b6\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u5076\u8054\u8bd5\u5242\uff0c\u5e76\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u7c7b\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u836f\u7269\u5206\u5b50\u4e2d\u3002\u5e76\u4e14\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u8bf8\u591a\u7814\u7a76\u56e2\u961f\u5df2\u7ecf\u6210\u529f\u8bbe\u8ba1\u51fa\u591a\u79cd\u5229\u7528\u70ef\u70c3\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\u6784\u5efa\u70f7\u57fa\u5364\u5206\u5b50\u7684\u5408\u6210\u8f6c\u5316\u7b56\u7565[1] (Scheme 1A, left and middle)\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u7b56\u7565\u5b58\u5728\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u5dee\u4ee5\u53ca\u539f\u5b50\u7ecf\u6d4e\u6027\u5dee\u7b49\u5f0a\u7aef\u3002\u53d7\u5230\u8fd1\u5e74\u6765\u53cc\u91cd\u94b4\/\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[2]\u4ee5\u53ca\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u70ef\u70c3\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66[3]\u76f8\u5173\u7814\u7a76\u62a5\u9053\u7684\u542f\u53d1\uff0c\u8fd9\u91cc\uff0c\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684Hirohisa Ohmiya\u4e0eKazunori Nagao\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u53cc\u91cd\u94b4\/\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u8102\u80aa\u65cf\u70ef\u70c3\u4e0ecollidine\u00b7HX\u76d0\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684\u70f7\u57fa\u5364\u5206\u5b50\u7684\u6784\u5efa\uff0c\u6d89\u53ca\u5173\u952e\u7684\u6781\u6027\u53cd\u8f6c\u7684\u8fc7\u7a0b (Scheme 1B)\u3002 \u9996\u5148\uff0c\u4f5c\u8005\u91c7\u75284-\u82ef\u57fa-1-\u4e01\u70ef1a\u4e0ecollidine\u00b7HBr\u76d02a\u4f5c\u4e3a\u6a21\u578b\u5e95\u7269\uff0c\u8fdb\u884c\u76f8\u5173\u53cd\u5e94\u6761\u4ef6\u7684\u4f18\u5316\u7b5b\u9009 (Table 1)\u3002\u8fdb\u800c\u786e\u5b9a\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\u4e3a\uff1a\u91c7\u7528Co-1\u4f5c\u4e3a\u50ac\u5316\u5242\uff0cIr(ppy)3\u4f5c\u4e3a\u5149\u50ac\u5316\u5242\uff0c34W\u84dd\u8272LED (0.5 cm away)\u4f5c\u4e3a\u5149\u6e90\uff0c\u5728THF\u53cd\u5e94\u6eb6\u5242\u4e2d\uff0c\u6700\u7ec8\u83b7\u5f9771%\u5206\u79bb\u6536\u7387\u7684\u4ea7\u72693aa\u3002 \u540c\u65f6\uff0c\u901a\u8fc7\u53cd\u5e94\u6761\u4ef6\u7684\u7a0d\u5fae\u4fee\u6539\uff0c\u8be5\u7b56\u7565\u8fd8\u53ef\u7528\u4e8e\u5176\u4ed6\u5364\u7d20\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66(Figure 1A)\u3002\u7d27\u63a5\u7740\uff0c\u4f5c\u8005\u5bf9\u4e00\u7cfb\u5217\u70ef\u70c3\u5e95\u7269\u4e0e\u5364\u7d20\u5e95\u7269 (Figure 1B)\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u3002 \u6b64\u5916\uff0c\u5bf9\u4e8eC\u2212X\u952e\u7684\u5f62\u6210\u53ef\u80fd\u5b58\u5728\u4e24\u79cd\u53ef\u80fd\u7684\u673a\u7406\uff0c\u5373\u70f7\u57fa\u81ea\u7531\u57fa\u6216\u70f7\u57fa\u94b4(III)\u4e0e\u5364\u5316\u94b4(III)\u7684SH2\u53cd\u5e94 (Scheme 1B)\u4ee5\u53ca\u5364\u5316\u7269\u9634\u79bb\u5b50\u4e0e\u70f7\u57fa\u94b4(IV)\u914d\u5408\u7269\u4e4b\u95f4\u7684SN2\u53cd\u5e94\u3002\u4e3a\u4e86\u533a\u5206\u4e0a\u8ff0\u7684\u53cd\u5e94\u673a\u7406\uff0c\u4f5c\u8005\u5bf9\u4e0a\u8ff0\u6c22\u5364\u5316\u8fc7\u7a0b\u7684\u53cd\u5e94\u673a\u7406\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76 \u00a0(Figure 2)\u3002 \u603b\u7ed3\uff1a \u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684Hirohisa Ohmiya\u4e0eKazunori Nagao\u8bfe\u9898\u7ec4\u62a5\u9053\u4e00\u79cd\u5168\u65b0\u7684\u53cc\u91cd\u94b4\/\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u8102\u80aa\u65cf\u70ef\u70c3\u4e0ecollidine\u00b7HX\u76d0\u7684\u6c22\u5364\u5316\u53cd\u5e94\u65b9\u6cd5\u5b66\uff0c\u8fdb\u800c\u6210\u529f\u5b8c\u6210\u4e00\u7cfb\u5217\u9ad8\u5ea6\u5b98\u80fd\u56e2\u5316\u7684\u70f7\u57fa\u5364\u5206\u5b50\u7684\u6784\u5efa\u3002\u8fd9\u4e00\u5168\u65b0\u7684\u6c22\u5364\u5316\u5408\u6210\u8f6c\u5316\u7b56\u7565\u5177\u6709\u5e95\u7269\u8303\u56f4\u5e7f\u6cdb\u3001\u4f18\u826f\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u4ee5\u53ca\u4f18\u826f\u7684\u539f\u5b50\u7ecf\u6d4e\u6027\u7b49\u4f18\u52bf\u3002 \u53c2\u8003\u6587\u732e\uff1a [1] S. W. M. Crossley, C. Obradors, R. M. Martinez, R. A. Shenvi, Chem. Rev. 2016, 116, 8912. doi:10.1021\/acs.chemrev.6b00334. [2] D. J. Wilger, J. M. M. Grandjean, T. R. Lammert, D. A. Nicewicz, Nat. Chem. 2014, 6, 720. doi:10.1038\/nchem.2000. [3] J. Kim, X. Sun, B. A. 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\u8bd1\u81eaChem-Station\u7f51\u7ad9\u65e5\u672c\u7248 \u539f\u6587\u94fe\u63a5\uff1a
\u5168\u5408\u6210\u7814\u7a76\u306f\u5275\u85ac\u5316\u5b66\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u306a\u308a\u5f97\u308b\u304b\uff1f<\/a><\/p>\n
\u7ffb\u8bd1\uff1a\u70b8\u9e21<\/p>\n
2024\u5e741\u6708\uff0cACS Medicinal Chemistry Letters\u00a0\u671f\u520a\u53d1\u5e03\u4e86\u4e00\u7bc7\u4ee5”\u5929\u7136\u7269\u5168\u5408\u6210\u81f3\u4eca\u4ecd\u7136\u662f\u521b\u836f\u5316\u5b66<\/strong>(<\/strong>\u533b\u836f\u5316\u5b66<\/strong>)<\/strong>\u4e00\u4e2a\u5f88\u597d\u7684\u8bad\u7ec3\u8bfe\u7a0b<\/strong>“\u4e3a\u4e3b\u9898\u7684\u89c2\u70b9\u8bba\u6587\uff0c2024\u5e746\u6708\u8be5\u7bc7\u8bba\u6587\u5f53\u9009\u4e3aACS Medicinal Chemistry Letters<\/strong>\u7684Most Read Article\u3002<\/p>\n

Total Synthesis as Training for Medicinal Chemistry
\nLewis D. Pennington
\nACS Med. Chem. Lett.<\/em>\u00a02024,\u00a015<\/em>,\u00a02<\/em>, 156\u2013158, DOI:\u00a0

10.1021\/acsmedchemlett.3c00556<\/em><\/a><\/p><\/blockquote>\n
\u8bba\u6587\u4f5c\u8005Lewis D. Pennington<\/strong>\u73b0\u62c5\u4efbMystic River Medicinal Chemistry, LLC\u7684\u987e\u95ee\uff0c\u5728\u7f8e\u56fd\u62e5\u670918\u9879\u4e13\u5229\uff0cWO\u7533\u8bf7\u4e13\u522937\u4ef6\uff0c\u53c2\u4e0e\u4e86\u4e24\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269\u7684\u7814\u53d1\u3002\u4ece2003\u5e74\u81f32015\u5e74\u5728Amgen\u5de5\u4f5c\u3002<\/p>\n
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\u5f53\u4eca\u7684\u836f\u7269\u5316\u5b66\u5bb6\u8981\u9762\u5bf9\u7684\u662f\u6781\u5177\u6311\u6218\u6027\u7684\u6cbb\u7597\u9776\u5411\uff0c\u8fd8\u6709\u8fc5\u901f\u4f18\u5316\u5404\u7c7b\u53c2\u6570\u4ee5\u53ca\u529f\u80fd\u4ea4\u53c9 (cross-functional)\u6027\u8d28\u7684\u9700\u8981\uff0c\u6240\u4ee5\u4ec5\u4ec5\u662f\u5408\u6210\u9886\u57df\u7684\u77e5\u8bc6\u65e0\u6cd5\u6ee1\u8db3\u73b0\u4ee3\u836f\u7269\u5316\u5b66\u5bb6\u4eec\u7684\u9700\u6c42\uff0c\u73b0\u4ee3\u836f\u7269\u5316\u5b66\u5bb6\u9700\u8981\u7684\u662f\u4ea4\u53c9\u9886\u57df\u7684\u77e5\u8bc6\u3002\u6b64\u5916\uff0c\u836f\u7269\u5316\u5b66\u4e5f\u6d89\u53ca\u6838\u9178\u3001\u80bd\u7c7b\u3001\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08Antibody-drug conjugate\uff0c\u7b80\u79f0\u4e3aADC\uff09\u7b49\u65b0\u578b\u836f\u7269\u5f62\u5f0f\u7684\u5f00\u53d1\uff0c\u4f46\u53e6\u4e00\u65b9\u9762\uff0c\u6709\u4eba\u6307\u51fa\u5728\u5236\u836f\u884c\u4e1a\u76f8\u8f83\u4e8e\u5168\u5408\u6210\uff0c\u5316\u5b66\u751f\u7269\u5b66\u548c\u8ba1\u7b97\u5316\u5b66\u7684\u8bad\u7ec3\u53ef\u80fd\u66f4\u4e3a\u6709\u76ca\u3002\u5f53\u4e0bAI\u521b\u836f\u662f\u5927\u52bf\u6240\u8d8b\uff0c\u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\u5168\u5408\u6210\u80fd\u591f\u6301\u7eed\u4e3a\u73b0\u4ee3\u521b\u836f\u5316\u5b66\u521b\u9020\u51fa\u4ef7\u503c\u5417\uff1f<\/p>\n
\u4f5c\u4e3a\u672c\u6587\u4f5c\u8005\u7684\u6211\u5bf9\u4ee5\u4e0a\u7591\u95ee\u7684\u56de\u7b54\u662f\u300cYES<\/strong>\u300d\uff0c\u7b14\u8005\u8fd8\u76f8\u4fe1\u4f5c\u4e3a\u836f\u7269\u5316\u5b66\u5bb6\u8bad\u7ec3\u8425\u7684\u5168\u5408\u6210\u7684\u5b66\u4e60\u542b\u91d1\u91cf\u4eca\u540e\u8fd8\u4f1a\u4e0d\u65ad\u5730”\u5347\u503c”\u3002<\/p>\n
\u5728\u73b0\u4ee3\u836f\u7269\u5316\u5b66\uff0c\u7279\u522b\u662f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u53d1\u4e2d\uff0c\u7ed3\u6784\u7684\u65b0\u9896\u6027\u548c\u5206\u5b50\u7684\u590d\u6742\u6027\u4e0d\u65ad\u589e\u52a0\uff0c\u800c\u4ee5\u5929\u7136\u7269\u4e3a\u57fa\u7840\u7684\u836f\u7269\u4f9d\u7136\u662f\u5c0f\u5206\u5b50\u5230\u4e2d\u5206\u5b50\u836f\u7269\u7684\u6a21\u677f\u3002\u6b64\u5916\uff0c\u6b63\u5982Fsp_{3<\/sub>\u8fd9\u4e00\u53c2\u6570\u6240\u4ee3\u8868\u7684\u90a3\u6837\uff0c\u7c7b\u4f3c\u5929\u7136\u7269\u7684\u4f4e\u5e73\u9762\u6027\u548c\u9ad8\u67d4\u6027\u7684\u5206\u5b50\u5728\u836f\u7269\u7814\u53d1\u4e2d\u53ef\u80fd\u5177\u6709\u8f83\u9ad8\u7684\u6210\u529f\u6982\u7387\uff0c\u56e0\u6b64\uff0c\u4ece\u5168\u5408\u6210\u4e2d\u53ef\u4ee5\u5b66\u5230\u5f88\u591a\u4e1c\u897f\u3002<\/p>\n}
\u5168\u5408\u6210\u548c\u521b\u836f\u5316\u5b66\u7684\u76f8\u4f3c\u6027<\/h4>\n
\u8bba\u6587<\/a>\u7684Figure 1\u5411\u6211\u4eec\u5c55\u793a\u4e86\u5168\u5408\u6210\u548c\u4f4e\u5206\u5b50\u521b\u836f\u5316\u5b66\u5404\u81ea\u7684\u7814\u7a76\u5faa\u73af\u7684\u5bf9\u6bd4\u56fe(\u4e0b\u56fe)\u3002<\/p>\n
\u5168\u5408\u6210\u4e5f\u8981\u836f\u7269\u5316\u5b66\u4e5f\u597d\uff0c\u7686\u4e3b\u8981\u805a\u7126\u4e8e\u5c0f\u5206\u5b50\uff0c\u901a\u8fc7\u53cd\u590d\u5730\u8bbe\u8ba1\u548c\u5408\u6210\u6765\u5f97\u5230\u76ee\u6807\u5206\u5b50\u3002\u5168\u5408\u6210\u4ece\u6613\u5f97\u7684\u539f\u6599\u5f00\u59cb\uff0c\u901a\u8fc7\u4e00\u7cfb\u5217\u5408\u6210\u6b65\u9aa4\u83b7\u5f97\u76ee\u6807\u5929\u7136\u7269\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u521b\u836f\u5316\u5b66\u4ece\u7b5b\u9009\u7b49\u65b9\u6cd5\u53d1\u73b0\u7684\u6d3b\u6027\u5316\u5408\u7269\u5f00\u59cb\uff0c\u901a\u8fc7\u8bbe\u8ba1\u548c\u5408\u6210\u884d\u751f\u7269\uff0c\u4ee5\u83b7\u5f97\u4e34\u5e8a\u5019\u9009\u836f\u7269\u4e3a\u76ee\u7684\u3002\u4e24\u8005\u90fd\u5728\u5206\u5b50\u8bbe\u8ba1\u3001\u5408\u6210\u8def\u5f84\u7684\u6784\u5efa\u3001\u4e2d\u95f4\u4f53\u6216\u7c7b\u4f3c\u7269\u7684\u5206\u6790\u4ee5\u53ca\u6709\u65f6\u8fdb\u884c\u751f\u7406\u6d3b\u6027\u6d4b\u8bd5\u65b9\u9762\u5b58\u5728\u5171\u901a\u70b9\u3002\u6b64\u5916\u8bba\u6587\u8fd8\u6307\u51fa\uff0c\u8fd1\u5e74\u6765\u4e0d\u4ec5\u5728\u836f\u7269\u5316\u5b66\u9886\u57df\uff0c\u800c\u4e14\u5728\u5168\u5408\u6210\u9886\u57df\u4e2dAI\u548c\u673a\u5668\u5b66\u4e60\u3001\u9ad8\u901a\u91cf\u6d4b\u8bd5\u7b49\u6280\u672f\u7684\u5e94\u7528\u4e5f\u5728\u589e\u52a0\u3002<\/p>\n
\u5168\u5408\u6210\u548c\u521b\u836f\u7684\u7814\u7a76\u6d41\u7a0b\u5bf9\u6bd4<\/h4>\n
\u7b14\u8005\u5217\u51fa\u4e86\u5168\u5408\u6210\u548c\u521b\u836f\u5404\u81ea\u7684\u7814\u7a76\u6d41\u7a0b\u8868(\u89c1\u4e0b\uff0c\u8868\u683c\u6839\u636e
\u8bba\u6587<\/a>\u8868\u683c\u7ffb\u8bd1)\u3002\u867d\u7136\u770b\u8d77\u6765\u4e24\u8005\u7684\u6d41\u7a0b\u90fd\u5dee\u4e0d\u591a\uff0c\u8fd8\u662f\u6709\u51e0\u4e2a\u4e0d\u540c\u7684\u73af\u8282\uff0c\u4f46\u6211\u4ecd\u65e7\u8ba4\u4e3a\u7814\u7a76\u8005\u5728\u5168\u5408\u6210\u9886\u57df\u79ef\u7d2f\u7684\u5404\u5f0f\u6280\u80fd\u4ecd\u80fd\u5728\u521b\u836f\u9886\u57df\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n
Table, \u00a0Analogous Conceptual Frameworks of Total Synthesis and Medicinal Chemistry<\/strong><\/p>\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

\u5168\u5408\u6210<\/strong><\/td>\n \u521b\u836f\u5316\u5b66<\/strong><\/td>\n<\/tr>\n

\u5929\u7136\u7269<\/td>\n \u4e34\u5e8a\u5019\u8865\u5316\u5408\u7269<\/td>\n<\/tr>\n

\u5316\u5b66\u53cd\u5e94<\/td>\n \u6784\u9020\u5f00\u5c55<\/td>\n<\/tr>\n

\u8bbe\u8ba1\u53cd\u5e94\u548c\u5408\u6210<\/td>\n \u8bbe\u8ba1\u836f\u7269\u30fb\u63a2\u9488<\/td>\n<\/tr>\n

\u9006\u5408\u6210\u89e3\u6790<\/td>\n De novo\u8bbe\u8ba1<\/td>\n<\/tr>\n

\u591a\u9636\u6bb5\u5408\u6210<\/td>\n Multi-parameter optimization(\u591a\u76ee\u6a19\u6700\u4f73\u63a7\u5236)<\/td>\n<\/tr>\n

\u6784\u9020\u6d3b\u6027\u76f8\u5173<\/td>\n \u6784\u9020\u6d3b\u6027\u76f8\u5173<\/td>\n<\/tr>\n

\u6536\u655b\u6027\u5408\u6210<\/p>\n
<\/td>\n
Divergent synthesis (\u53d1\u6563\u6027\u5408\u6210)<\/td>\n<\/tr>\n

\u6700\u957f\u7684\u7ebf\u6027\u987a\u5e8f<\/td>\n derivatives design cycle<\/td>\n<\/tr>\n

\u6536\u7387<\/td>\n \u63d0\u9ad8\u6d3b\u6027<\/td>\n<\/tr>\n

\u539f\u5b50\u7ecf\u6d4e\u6027<\/td>\n \u914d\u4f53\u6548\u7387<\/td>\n<\/tr>\n

\u603b\u6536\u7387<\/td>\n \u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/td>\n<\/tr>\n

\u5316\u5b66\u53cd\u5e94\u6027<\/td>\n \u4ee3\u8c22\u7a33\u5b9a\u6027<\/td>\n<\/tr>\n

\u8fc7\u6e21\u6001<\/td>\n \u7ed3\u5408\u6a21\u5f0f<\/td>\n<\/tr>\n

\u4e32\u7ea7\u53cd\u5e94<\/td>\n Activity cliffs<\/td>\n<\/tr>\n

\u7acb\u4f53\u9009\u62e9\u6027<\/td>\n Eudysmic ratio<\/td>\n<\/tr>\n

\u4f4d\u7f6e\u9009\u62e9\u6027\u548c\u5316\u5b66\u9009\u62e9\u6027<\/td>\n \u4ee3\u8c22\u8f6f\u70b9(\u836f\u7269\u5206\u5b50\u4e2d\u5bb9\u6613\u88ab\u9176\u89e3\u6216\u5176\u4ed6\u4ee3\u8c22\u53cd\u5e94\u4f5c\u7528\u7684\u90e8\u4f4d)<\/td>\n<\/tr>\n<\/thead>\n<\/table>\n
\u4ece\u4e0a\u8868\u7684\u5bf9\u6bd4\u4e2d\u6211\u4eec\u4e0d\u96be\u770b\u51fa: \u5f53\u5168\u5408\u6210\u7814\u7a76\u8005\u8f6c\u6218\u521b\u836f\u9886\u57df\u65f6\uff0c\u53ea\u9700\u8981\u8865\u4e60\u4ee3\u8c22\u3001\u914d\u4f53\u6548\u7387\u3001\u5b89\u5168\u6027\u9a8c\u8bc1\u7b49\u57fa\u7840\u77e5\u8bc6\u5373\u53ef\u3002<\/p>\n
\u6d3b\u6027\u60ac\u5d16\uff08<\/strong>Activity cliffs<\/strong>)<\/strong>\u662f\u6307\u5728\u6784\u6548\u5173\u7cfb\uff08SAR\uff09\u7a7a\u95f4\u4e2d\u7684\u4e0d\u8fde\u7eed\u533a\u57df\uff0c\u5176\u4e2d\u6d3b\u6027\u5316\u5408\u7269\u7684\u5fae\u5c0f\u7ed3\u6784\u53d8\u5316\u4f1a\u5e26\u6765\u663e\u8457\u7684\u6d3b\u6027\u63d0\u5347\u7684\u4e00\u79cd\u73b0\u8c61\u3002\u8be5\u73b0\u8c61\u7531J. Bajorath\u4e8e2012\u5e74\u63d0\u51fa\u3002\u7531\u4e8e\u5316\u5408\u7269\u7684\u6d3b\u6027\u5b9b\u5982\u60ac\u5d16\u4e00\u6837\u6025\u5267\u63d0\u5347\uff0c\u56e0\u6b64\u5f97\u540d\u3002<\/p>\n
(\u5f15\u7528\u81eahttps:\/\/www.titech.ac.jp\/news\/2020\/047838<\/a>)<\/p>\n
\u7ed3\u675f\u8bed<\/h4>\n
\u7b14\u8005\u7684\u89c2\u70b9: \u867d\u7136\u8fd130\u5e74\u521b\u836f\u5316\u5b66\u9769\u65b0\u4e0d\u65ad\uff0c\u4f46\u5168\u5408\u6210\u81f3\u4eca\u4ecd\u7136\u662f\u5b66\u672f\u754c\u57f9\u517b\u836f\u7269\u5316\u5b66\u5bb6\u7684\u6700\u4f73”\u8bad\u7ec3\u8425”\u4e4b\u4e00\u3002\u5728\u5168\u5408\u6210\u9886\u57df\uff0c\u53ef\u4ee5\u79ef\u7d2f\u591a\u79cd\u5316\u5b66\u53cd\u5e94\u7684\u7ecf\u9a8c\uff0c\u53ef\u4ee5\u5b66\u4e60\u9ad8\u6548\u5408\u6210\u590d\u6742\u5206\u5b50\u7684\u624b\u6cd5\u3002\u5728\u5168\u5408\u6210\u9886\u57df\u57f9\u517b\u7684\u6280\u80fd\u53ef\u4ee5\u8f7b\u677e\u8fd0\u7528\u5728\u521b\u836f\u5316\u5b66\u9886\u57df\uff0c\u751a\u81f3\u5728\u5be1\u6838\u9178\u3001\u5be1\u80bd\u3001\u5be1\u7cd6\u3001\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u7b49\u975e\u4f4e\u5206\u5b50\u7684\u6a21\u6001\u4e2d\u4e5f\u6709\u7528\u6b66\u4e4b\u5904\u3002\u5728\u5168\u5408\u6210\u6216\u5728\u521b\u836f\uff0c\u90fd\u4f1a\u7ecf\u5386\u65e0\u6570\u6b21\u5931\u8d25\u751a\u81f3\u66f2\u6298\uff0c\u4f46\u6700\u7ec8\u7684\u80dc\u5229\u90fd\u9700\u8981\u7814\u7a76\u8005\u6709\u9ad8\u77bb\u8fdc\u77a9\u7684\u8ba1\u5212\uff0c\u968f\u673a\u5e94\u53d8\u7684\u80fd\u529b\u548c\u767e\u6298\u4e0d\u6320\u7684\u6bc5\u529b\u3002<\/p>\n
\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u521b\u836f\u5316\u5b66\u4e2d\u76f8\u8f83\u4e8e\u5168\u5408\u6210\uff0c\u6240\u4f7f\u7528\u7684\u53cd\u5e94\u6709\u504f\u5411\u6027\u662f\u5ba2\u89c2\u5b58\u5728\u7684\uff0c\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u5728\u521b\u836f\u5316\u5b66\u4e2d\uff0c\u8f6c\u4f4d\u53cd\u5e94\u548c\u590d\u5206\u89e3\u53cd\u5e94\u7b49\u7684\u4f7f\u7528\u9891\u7387\u4e0d\u9ad8\uff0c\u800c\u7f29\u5408\u53cd\u5e94\u548c\u5076\u8054\u53cd\u5e94\u5360\u636e\u4e86\u8f83\u5927\u7684\u6bd4\u91cd\u3002<\/p>\n
\u5229\u7528\u5168\u5408\u6210\u8fd9\u4e00\u5728\u5b66\u672f\u754c\u4e4b\u5916\u5f88\u96be\u5b66\u5230\u7684\u6280\u80fd\uff0c\u53ef\u4ee5\u53e9\u5f00\u5236\u836f\u548c\u521b\u836f\u9886\u57df\u7684\u5927\u95e8\uff0c\u5f00\u8f9f\u4e00\u6761\u9887\u5177\u4f18\u52bf\u7684\u804c\u4e1a\u9053\u8def\u3002\u6211\u76f8\u4fe1\uff0c\u8fdb\u884c\u5168\u5408\u6210\u7814\u7a76\u57f9\u517b\u7684\u6280\u80fd\u5347\u7ea7\uff0c\u4ee5\u53ca\u4eb2\u624b\u5408\u6210\u6709\u7528\u7684\u5929\u7136\u4ea7\u7269\u7684\u4e50\u8da3\u5c06\u6301\u7eed\u5438\u5f15\u5316\u5b66\u5bb6\u4eec\u7684\u70ed\u60c5\u3002<\/p>\n
<\/p>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u8bd1\u81eaChem-Station\u7f51\u7ad9\u65e5\u672c\u7248 \u539f\u6587\u94fe\u63a5\uff1a\u5168\u5408\u6210\u7814\u7a76\u306f\u5275\u85ac\u5316\u5b66\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u306a\u308a\u5f97\u308b\u304b\uff1f \u7ffb\u8bd1\uff1a\u70b8\u9e21 2024\u5e741\u6708\uff0cACS Medicinal Chemistry Letters\u00a0\u671f\u520a\u53d1\u5e03\u4e86\u4e00\u7bc7\u4ee5”\u5929\u7136\u7269\u5168\u5408\u6210\u81f3\u4eca\u4ecd\u7136\u662f\u521b\u836f\u5316\u5b66(\u533b\u836f\u5316\u5b66)\u4e00\u4e2a\u5f88\u597d\u7684\u8bad\u7ec3\u8bfe\u7a0b“\u4e3a\u4e3b\u9898\u7684\u89c2\u70b9\u8bba\u6587\uff0c2024\u5e746\u6708\u8be5\u7bc7\u8bba\u6587\u5f53\u9009\u4e3aACS Medicinal Chemistry Letters\u7684Most Read Article\u3002 Total Synthesis as Training for Medicinal Chemistry Lewis D. Pennington ACS Med. Chem. Lett.\u00a02024,\u00a015,\u00a02, 156\u2013158, DOI:\u00a010.1021\/acsmedchemlett.3c00556 \u8bba\u6587\u4f5c\u8005Lewis D. Pennington\u73b0\u62c5\u4efbMystic River Medicinal Chemistry, LLC\u7684\u987e\u95ee\uff0c\u5728\u7f8e\u56fd\u62e5\u670918\u9879\u4e13\u5229\uff0cWO\u7533\u8bf7\u4e13\u522937\u4ef6\uff0c\u53c2\u4e0e\u4e86\u4e24\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269\u7684\u7814\u53d1\u3002\u4ece2003\u5e74\u81f32015\u5e74\u5728Amgen\u5de5\u4f5c\u3002 \u5168\u5408\u6210\u548c\u521b\u836f\u5316\u5b66 \u5728\u6709\u673a\u5408\u6210\u5316\u5b66\u5927\u7c7b\u4e2d\uff0c\u5168\u5408\u6210\u662f\u4e00\u9879\u901a\u8fc7\u8bbe\u8ba1\u5929\u7136\u7269\u7684\u5408\u6210\u8def\u5f84\u5e76\u627e\u5230\u6700\u5408\u9002\u7684\u5408\u6210\u8def\u5f84\uff0c\u4ece\u800c\u4ee5\u8f83\u9ad8\u6536\u7387\u5f97\u5230\u76ee\u7684\u7269\u7684\u4e00\u4e2a\u70ed\u95e8\u7684\u7814\u7a76\u5206\u652f\u3002\u5b66\u4e60\u5168\u5408\u6210\u4e0d\u4ec5\u8981\u5b66\u4e60\u6709\u673a\u5408\u6210\uff0c\u8fd8\u8981\u5b66\u4e60\u5982\u4f55\u786e\u5b9a\u5206\u5b50\u7ed3\u6784\uff0c\u6709\u65f6\u8fd8\u8981\u6d89\u730e\u5206\u5b50\u7684\u751f\u7406\u6d3b\u6027\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u8fd8\u4f1a\u8bbe\u8ba1\u65b0\u53cd\u5e94\u7684\u5f00\u53d1\uff0c\u53ef\u4ee5\u8bf4\u662f\u4e00\u4e2a\u9700\u8981\u5b66\u4e60\u5f88\u591a\u77e5\u8bc6\u7684\u7814\u7a76\u5206\u652f\u3002 \u5f53\u4eca\u7684\u836f\u7269\u5316\u5b66\u5bb6\u8981\u9762\u5bf9\u7684\u662f\u6781\u5177\u6311\u6218\u6027\u7684\u6cbb\u7597\u9776\u5411\uff0c\u8fd8\u6709\u8fc5\u901f\u4f18\u5316\u5404\u7c7b\u53c2\u6570\u4ee5\u53ca\u529f\u80fd\u4ea4\u53c9 (cross-functional)\u6027\u8d28\u7684\u9700\u8981\uff0c\u6240\u4ee5\u4ec5\u4ec5\u662f\u5408\u6210\u9886\u57df\u7684\u77e5\u8bc6\u65e0\u6cd5\u6ee1\u8db3\u73b0\u4ee3\u836f\u7269\u5316\u5b66\u5bb6\u4eec\u7684\u9700\u6c42\uff0c\u73b0\u4ee3\u836f\u7269\u5316\u5b66\u5bb6\u9700\u8981\u7684\u662f\u4ea4\u53c9\u9886\u57df\u7684\u77e5\u8bc6\u3002\u6b64\u5916\uff0c\u836f\u7269\u5316\u5b66\u4e5f\u6d89\u53ca\u6838\u9178\u3001\u80bd\u7c7b\u3001\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08Antibody-drug conjugate\uff0c\u7b80\u79f0\u4e3aADC\uff09\u7b49\u65b0\u578b\u836f\u7269\u5f62\u5f0f\u7684\u5f00\u53d1\uff0c\u4f46\u53e6\u4e00\u65b9\u9762\uff0c\u6709\u4eba\u6307\u51fa\u5728\u5236\u836f\u884c\u4e1a\u76f8\u8f83\u4e8e\u5168\u5408\u6210\uff0c\u5316\u5b66\u751f\u7269\u5b66\u548c\u8ba1\u7b97\u5316\u5b66\u7684\u8bad\u7ec3\u53ef\u80fd\u66f4\u4e3a\u6709\u76ca\u3002\u5f53\u4e0bAI\u521b\u836f\u662f\u5927\u52bf\u6240\u8d8b\uff0c\u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\u5168\u5408\u6210\u80fd\u591f\u6301\u7eed\u4e3a\u73b0\u4ee3\u521b\u836f\u5316\u5b66\u521b\u9020\u51fa\u4ef7\u503c\u5417\uff1f \u4f5c\u4e3a\u672c\u6587\u4f5c\u8005\u7684\u6211\u5bf9\u4ee5\u4e0a\u7591\u95ee\u7684\u56de\u7b54\u662f\u300cYES\u300d\uff0c\u7b14\u8005\u8fd8\u76f8\u4fe1\u4f5c\u4e3a\u836f\u7269\u5316\u5b66\u5bb6\u8bad\u7ec3\u8425\u7684\u5168\u5408\u6210\u7684\u5b66\u4e60\u542b\u91d1\u91cf\u4eca\u540e\u8fd8\u4f1a\u4e0d\u65ad\u5730”\u5347\u503c”\u3002 \u5728\u73b0\u4ee3\u836f\u7269\u5316\u5b66\uff0c\u7279\u522b\u662f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u53d1\u4e2d\uff0c\u7ed3\u6784\u7684\u65b0\u9896\u6027\u548c\u5206\u5b50\u7684\u590d\u6742\u6027\u4e0d\u65ad\u589e\u52a0\uff0c\u800c\u4ee5\u5929\u7136\u7269\u4e3a\u57fa\u7840\u7684\u836f\u7269\u4f9d\u7136\u662f\u5c0f\u5206\u5b50\u5230\u4e2d\u5206\u5b50\u836f\u7269\u7684\u6a21\u677f\u3002\u6b64\u5916\uff0c\u6b63\u5982Fsp3\u8fd9\u4e00\u53c2\u6570\u6240\u4ee3\u8868\u7684\u90a3\u6837\uff0c\u7c7b\u4f3c\u5929\u7136\u7269\u7684\u4f4e\u5e73\u9762\u6027\u548c\u9ad8\u67d4\u6027\u7684\u5206\u5b50\u5728\u836f\u7269\u7814\u53d1\u4e2d\u53ef\u80fd\u5177\u6709\u8f83\u9ad8\u7684\u6210\u529f\u6982\u7387\uff0c\u56e0\u6b64\uff0c\u4ece\u5168\u5408\u6210\u4e2d\u53ef\u4ee5\u5b66\u5230\u5f88\u591a\u4e1c\u897f\u3002 \u5168\u5408\u6210\u548c\u521b\u836f\u5316\u5b66\u7684\u76f8\u4f3c\u6027 \u8bba\u6587\u7684Figure 1\u5411\u6211\u4eec\u5c55\u793a\u4e86\u5168\u5408\u6210\u548c\u4f4e\u5206\u5b50\u521b\u836f\u5316\u5b66\u5404\u81ea\u7684\u7814\u7a76\u5faa\u73af\u7684\u5bf9\u6bd4\u56fe(\u4e0b\u56fe)\u3002 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\u5168\u5408\u6210\u548c\u521b\u836f\u7684\u7814\u7a76\u6d41\u7a0b\u5bf9\u6bd4 \u7b14\u8005\u5217\u51fa\u4e86\u5168\u5408\u6210\u548c\u521b\u836f\u5404\u81ea\u7684\u7814\u7a76\u6d41\u7a0b\u8868(\u89c1\u4e0b\uff0c\u8868\u683c\u6839\u636e\u8bba\u6587\u8868\u683c\u7ffb\u8bd1)\u3002\u867d\u7136\u770b\u8d77\u6765\u4e24\u8005\u7684\u6d41\u7a0b\u90fd\u5dee\u4e0d\u591a\uff0c\u8fd8\u662f\u6709\u51e0\u4e2a\u4e0d\u540c\u7684\u73af\u8282\uff0c\u4f46\u6211\u4ecd\u65e7\u8ba4\u4e3a\u7814\u7a76\u8005\u5728\u5168\u5408\u6210\u9886\u57df\u79ef\u7d2f\u7684\u5404\u5f0f\u6280\u80fd\u4ecd\u80fd\u5728\u521b\u836f\u9886\u57df\u53d1\u6325\u4f5c\u7528\u3002 Table, \u00a0Analogous Conceptual Frameworks of Total Synthesis and Medicinal Chemistry \u5168\u5408\u6210 \u521b\u836f\u5316\u5b66 \u5929\u7136\u7269 \u4e34\u5e8a\u5019\u8865\u5316\u5408\u7269 \u5316\u5b66\u53cd\u5e94 \u6784\u9020\u5f00\u5c55 \u8bbe\u8ba1\u53cd\u5e94\u548c\u5408\u6210 \u8bbe\u8ba1\u836f\u7269\u30fb\u63a2\u9488 \u9006\u5408\u6210\u89e3\u6790 De novo\u8bbe\u8ba1 \u591a\u9636\u6bb5\u5408\u6210 Multi-parameter optimization(\u591a\u76ee\u6a19\u6700\u4f73\u63a7\u5236) \u6784\u9020\u6d3b\u6027\u76f8\u5173 \u6784\u9020\u6d3b\u6027\u76f8\u5173 \u6536\u655b\u6027\u5408\u6210 Divergent synthesis (\u53d1\u6563\u6027\u5408\u6210) \u6700\u957f\u7684\u7ebf\u6027\u987a\u5e8f derivatives design cycle \u6536\u7387 \u63d0\u9ad8\u6d3b\u6027 \u539f\u5b50\u7ecf\u6d4e\u6027 \u914d\u4f53\u6548\u7387 \u603b\u6536\u7387 \u5b89\u5168\u6027\u548c\u6709\u6548\u6027 \u5316\u5b66\u53cd\u5e94\u6027 \u4ee3\u8c22\u7a33\u5b9a\u6027 \u8fc7\u6e21\u6001 \u7ed3\u5408\u6a21\u5f0f \u4e32\u7ea7\u53cd\u5e94 Activity cliffs \u7acb\u4f53\u9009\u62e9\u6027 Eudysmic ratio \u4f4d\u7f6e\u9009\u62e9\u6027\u548c\u5316\u5b66\u9009\u62e9\u6027 \u4ee3\u8c22\u8f6f\u70b9(\u836f\u7269\u5206\u5b50\u4e2d\u5bb9\u6613\u88ab\u9176\u89e3\u6216\u5176\u4ed6\u4ee3\u8c22\u53cd\u5e94\u4f5c\u7528\u7684\u90e8\u4f4d) \u4ece\u4e0a\u8868\u7684\u5bf9\u6bd4\u4e2d\u6211\u4eec\u4e0d\u96be\u770b\u51fa: \u5f53\u5168\u5408\u6210\u7814\u7a76\u8005\u8f6c\u6218\u521b\u836f\u9886\u57df\u65f6\uff0c\u53ea\u9700\u8981\u8865\u4e60\u4ee3\u8c22\u3001\u914d\u4f53\u6548\u7387\u3001\u5b89\u5168\u6027\u9a8c\u8bc1\u7b49\u57fa\u7840\u77e5\u8bc6\u5373\u53ef\u3002 \u6d3b\u6027\u60ac\u5d16\uff08Activity cliffs)\u662f\u6307\u5728\u6784\u6548\u5173\u7cfb\uff08SAR\uff09\u7a7a\u95f4\u4e2d\u7684\u4e0d\u8fde\u7eed\u533a\u57df\uff0c\u5176\u4e2d\u6d3b\u6027\u5316\u5408\u7269\u7684\u5fae\u5c0f\u7ed3\u6784\u53d8\u5316\u4f1a\u5e26\u6765\u663e\u8457\u7684\u6d3b\u6027\u63d0\u5347\u7684\u4e00\u79cd\u73b0\u8c61\u3002\u8be5\u73b0\u8c61\u7531J. Bajorath\u4e8e2012\u5e74\u63d0\u51fa\u3002\u7531\u4e8e\u5316\u5408\u7269\u7684\u6d3b\u6027\u5b9b\u5982\u60ac\u5d16\u4e00\u6837\u6025\u5267\u63d0\u5347\uff0c\u56e0\u6b64\u5f97\u540d\u3002 (\u5f15\u7528\u81eahttps:\/\/www.titech.ac.jp\/news\/2020\/047838) \u7ed3\u675f\u8bed \u7b14\u8005\u7684\u89c2\u70b9: \u867d\u7136\u8fd130\u5e74\u521b\u836f\u5316\u5b66\u9769\u65b0\u4e0d\u65ad\uff0c\u4f46\u5168\u5408\u6210\u81f3\u4eca\u4ecd\u7136\u662f\u5b66\u672f\u754c\u57f9\u517b\u836f\u7269\u5316\u5b66\u5bb6\u7684\u6700\u4f73”\u8bad\u7ec3\u8425”\u4e4b\u4e00\u3002\u5728\u5168\u5408\u6210\u9886\u57df\uff0c\u53ef\u4ee5\u79ef\u7d2f\u591a\u79cd\u5316\u5b66\u53cd\u5e94\u7684\u7ecf\u9a8c\uff0c\u53ef\u4ee5\u5b66\u4e60\u9ad8\u6548\u5408\u6210\u590d\u6742\u5206\u5b50\u7684\u624b\u6cd5\u3002\u5728\u5168\u5408\u6210\u9886\u57df\u57f9\u517b\u7684\u6280\u80fd\u53ef\u4ee5\u8f7b\u677e\u8fd0\u7528\u5728\u521b\u836f\u5316\u5b66\u9886\u57df\uff0c\u751a\u81f3\u5728\u5be1\u6838\u9178\u3001\u5be1\u80bd\u3001\u5be1\u7cd6\u3001\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u7b49\u975e\u4f4e\u5206\u5b50\u7684\u6a21\u6001\u4e2d\u4e5f\u6709\u7528\u6b66\u4e4b\u5904\u3002\u5728\u5168\u5408\u6210\u6216\u5728\u521b\u836f\uff0c\u90fd\u4f1a\u7ecf\u5386\u65e0\u6570\u6b21\u5931\u8d25\u751a\u81f3\u66f2\u6298\uff0c\u4f46\u6700\u7ec8\u7684\u80dc\u5229\u90fd\u9700\u8981\u7814\u7a76\u8005\u6709\u9ad8\u77bb\u8fdc\u77a9\u7684\u8ba1\u5212\uff0c\u968f\u673a\u5e94\u53d8\u7684\u80fd\u529b\u548c\u767e\u6298\u4e0d\u6320\u7684\u6bc5\u529b\u3002 […]","protected":false},"author":26,"featured_media":50916,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[275,4412,1056,2905],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/08\/image001.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-dfd","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50915"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=50915"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50915\/revisions"}],"predecessor-version":[{"id":50919,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50915\/revisions\/50919"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/50916"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=50915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=50915"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=50915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":50902,"date":"2024-08-14T08:34:29","date_gmt":"2024-08-14T00:34:29","guid":{"rendered":"\/\/www.gsbet888.com\/?p=50902"},"modified":"2024-08-14T11:06:38","modified_gmt":"2024-08-14T03:06:38","slug":"%e3%80%8cspotlight-research%e3%80%8d%e6%96%b0%e5%9e%8bo-phenylene-bisurea-opbu%e5%82%ac%e5%8c%96%e5%89%82","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/interview\/2024\/08\/%e3%80%8cspotlight-research%e3%80%8d%e6%96%b0%e5%9e%8bo-phenylene-bisurea-opbu%e5%82%ac%e5%8c%96%e5%89%82.html","title":{"rendered":"\u300cSpotlight Research\u300d\u65b0\u578bO-Phenylene Bisurea (OPBU)\u50ac\u5316\u5242"},"content":{"rendered":"
\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a<\/p>\n
\u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u52a0\u65af\u5766\u798f\u5927\u5b66\u7684\u5f20\u5609\u535a\u58eb\u4e3a\u6211\u4eec\u5206\u4eab\u3002<\/p>\n
2024\u5e748\u67085\u65e5\uff0cJ. Am. Chem. Soc.<\/em>\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u65af\u5766\u798f\u5927\u5b66\u7684Robert M. Waymouth\u6559\u6388\u56e2\u961f\u9898\u4e3a\u300cHighly Selective\u00a0O<\/em>-Phenylene Bisurea Catalysts for ROP: Stabilization of Oxyanion Transition State by a Semiflexible Hydrogen Bond Pocket\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684O-Phenylene Bisurea (OPBU)\u50ac\u5316\u5242\uff0c\u7528\u4e8e\u73af\u72b6\u5f00\u94fe\u805a\u5408\uff08ROP\uff09\u3002\u8fd9\u79cd\u50ac\u5316\u5242\u4e0d\u4ec5\u53cd\u5e94\u8fc5\u901f\u3001\u53ef\u8c03\u6027\u5f3a\uff0c\u800c\u4e14\u9009\u62e9\u6027\u4f18\u5f02\uff0c\u6bd4\u4f20\u7edf\u50ac\u5316\u5242\uff08\u5982\u786b\u8132\u3001\u5c3f\u7d20\u548cTBD\uff09\u9ad8\u51fa8\u5230120\u500d\u3002OPBU\u50ac\u5316\u5242\u80fd\u5728\u51e0\u79d2\u5230\u51e0\u5206\u949f\u5185\u5b9e\u73b0\u8d85\u8fc795%\u7684\u9ad8\u8f6c\u5316\u7387\uff0c\u4ea7\u751f\u5206\u5b50\u91cf\u7cbe\u51c6\u4e14\u5206\u6563\u5ea6\u6781\u4f4e\u7684\u805a\u5408\u7269\u3002<\/p>\n
<\/p>\n

\n
\u201cHighly Selective\u00a0O<\/em>-Phenylene Bisurea Catalysts for ROP: Stabilization of Oxyanion Transition State by a Semiflexible Hydrogen Bond Pocket<\/p>\n
Jia Zhang, Kai Hin Lui, Rachele Zunino, Yuan Jia, Romain Morodo, Niklas Warlin, James L. Hedrick, Giovanni Talarico, Robert M. Waymouth*<\/p>\n
J. Am. Chem. Soc.\u00a0<\/em>2024, <\/strong>ASAP, doi:

10.1021\/jacs.4c04740<\/a>\u201d<\/p>\n<\/blockquote>\n
Q1. <\/strong>\u8bf7\u5bf9\u201c<\/strong>Highly Selective\u00a0O<\/em>-Phenylene Bisurea Catalysts for ROP: Stabilization of Oxyanion Transition State by a Semiflexible Hydrogen Bond Pocket\u201d<\/strong>\u4f5c<\/strong>\u4e00\u4e2a\u7b80\u5355\u4ecb\u7ecd\u3002<\/strong><\/h4>\n
\u6211\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684O-Phenylene Bisurea (OPBU)\u50ac\u5316\u5242\uff0c\u7528\u4e8e\u73af\u72b6\u5f00\u94fe\u805a\u5408\uff08ROP\uff09\u3002\u8fd9\u79cd\u50ac\u5316\u5242\u4e0d\u4ec5\u53cd\u5e94\u8fc5\u901f\u3001\u53ef\u8c03\u6027\u5f3a\uff0c\u800c\u4e14\u9009\u62e9\u6027\u4f18\u5f02\uff0c\u6bd4\u4f20\u7edf\u50ac\u5316\u5242\uff08\u5982\u786b\u8132\u3001\u5c3f\u7d20\u548cTBD\uff09\u9ad8\u51fa8\u5230120\u500d\u3002OPBU\u50ac\u5316\u5242\u80fd\u5728\u51e0\u79d2\u5230\u51e0\u5206\u949f\u5185\u5b9e\u73b0\u8d85\u8fc795%\u7684\u9ad8\u8f6c\u5316\u7387\uff0c\u4ea7\u751f\u5206\u5b50\u91cf\u7cbe\u51c6\u4e14\u5206\u6563\u5ea6\u6781\u4f4e\u7684\u805a\u5408\u7269\u3002\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\uff08DFT\uff09\u8ba1\u7b97\u663e\u793a\uff0c\u50ac\u5316\u5242\u901a\u8fc7\u7c7b\u4f3c\u4e8e\u9176\u50ac\u5316\u4e2d\u7684\u201c\u6c27\u8d1f\u79bb\u5b50\u5b54\u6d1e\u201d\u7684\u6c22\u952e\u53e3\u888b\u7a33\u5b9a\u6c27\u8d1f\u79bb\u5b50\u8fc7\u6e21\u6001\u3002\u8fd9\u4e9b\u65b0\u578b\u50ac\u5316\u5242\u5728\u6709\u673a\u50ac\u5316\u9886\u57df\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\uff0c\u5176\u4f18\u8d8a\u7684\u6027\u80fd\u548c\u53ef\u8c03\u6027\u4e3a\u63a7\u5236\u805a\u5408\u7269\u5408\u6210\u5e26\u6765\u4e86\u65b0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n
In this study, we introduced a new type of O-Phenylene Bisurea (OPBU) catalyst for ring-opening polymerization (ROP). This catalyst is not only fast and easily tunable but also exhibits exceptional selectivity, outperforming traditional catalysts (such as thiourea, urea, and TBD) by 8 to 120 times. OPBU catalysts enable ROP of various monomers, achieving over 95% conversion in seconds to minutes, producing polymers with precise molecular weights and very low dispersity (\u0110 \u2248 1.01). Density functional theory (DFT) calculations reveal that the catalysts stabilize the oxyanion transition state via a hydrogen bond pocket similar to the “oxyanion hole” in enzymatic catalysis. These new insights provide a new class of organic catalysts with excellent performance and tunability, opening up new opportunities for controlled polymer synthesis.<\/p>\n
Q2. <\/strong>\u6709\u5173\u672c\u6b21\u7814\u7a76\u7684\u65f6\u5019\u9047\u5230\u8fc7\u600e\u6837\u7684\u56f0\u96be\u5462\uff1f\u53c8\u662f\u600e\u6837\u514b\u670d\u7684\u5462<\/strong><\/h4>\n
\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u9047\u5230\u4e86\u4e24\u4e2a\u4e3b\u8981\u56f0\u96be\u3002\u9996\u5148\u662f\u5982\u4f55\u5bf9\u9009\u62e9\u6027\u8fdb\u884c\u5b9a\u91cf\u6d4b\u91cf\u3002\u4ee5\u5f80\u6587\u732e\u4e2d\u62a5\u544a\u7684\u65b0\u578bROP\u50ac\u5316\u5242\u901a\u5e38\u4ec5\u4f9d\u8d56GPC\u7ed3\u679c\uff0c\u7531\u4e8eGPC\u7684\u7cbe\u5ea6\u6709\u9650\uff0c\u96be\u4ee5\u76f4\u63a5\u6bd4\u8f83\u4e0d\u540c\u50ac\u5316\u5242\u7684\u9009\u62e9\u6027\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u6211\u4eec\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u5b9e\u9a8c\uff0c\u4ee5\u66f4\u51c6\u786e\u5730\u4f30\u7b97\u94fe\u589e\u957f\u4e0e\u94fe\u8f6c\u79fb\u7684\u9009\u62e9\u6bd4\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u5bf9\u8bb8\u591a\u4e4b\u524d\u50ac\u5316\u5242\u7684\u51c6\u786e\u6bd4\u8f83\u3002<\/p>\n
\u5176\u6b21\uff0c\u5173\u4e8eDFT\u8ba1\u7b97\uff0c\u6211\u4eec\u9762\u4e34\u4e86\u590d\u6742\u7684\u6311\u6218\u3002\u53cd\u5e94\u7269\u590d\u5408\u7269\u53ef\u4ee5\u5f62\u6210\u591a\u79cd\u4e0d\u540c\u7684\u6784\u8c61\uff0c\u4f7f\u5f97\u8ba1\u7b97\u53d8\u5f97\u975e\u5e38\u590d\u6742\u3002\u5c3d\u7ba1\u8fd9\u65b9\u9762\u6211\u4e0d\u662f\u4e13\u5bb6\uff0c\u4f46\u6211\u4eec\u7684\u5408\u4f5c\u4f19\u4f34Rachele Zunino\uff08\u5171\u540c\u4e00\u4f5c\uff09\u975e\u5e38\u51fa\u8272\u5730\u89e3\u51b3\u4e86\u8fd9\u4e2a\u95ee\u9898\uff0c\u6210\u529f\u5730\u5c55\u793a\u4e86\u5408\u7406\u7684\u53cd\u5e94\u673a\u5236\u3002<\/p>\n
We encountered two main difficulties in this research. First was developing a quantitative measurement of the selectivity parameter. Previously, new selective ROP catalysts reported in the literature usually relied solely on GPC results, which are not precise enough for good comparison between different catalysts. To address this, we designed kinetic experiments to provide a more accurate estimation of the selectivity ratio of chain growth versus chain transfer, allowing us to make fair comparisons among many previous catalysts.<\/p>\n
Second, regarding DFT calculations, we faced challenges due to the many different conformations that reactant complexes can access, making the computations very complex. Although I am not an expert in this area, our collaborator Rachele Zunino brilliantly tackled this issue and was able to demonstrate a reasonable reaction mechanism.<\/p>\n
Q3. <\/strong>\u672c\u6b21\u7814\u7a76\u4e3b\u4f53\uff0c\u6709\u6ca1\u6709\u4ec0\u4e48\u8ba9\u60a8\u611f\u89c9\u7279\u522b\u8f9b\u82e6\u548c\u70e7\u8111\u5462\uff1f<\/strong><\/h4>\n
\u8bba\u6587\u6700\u5927\u7684\u5356\u70b9\u80af\u5b9a\u662f\u50ac\u5316\u5242\u7684\u7ed3\u6784\u8bbe\u8ba1\uff0c \u4f46\u662f\u7814\u7a76\u8fc7\u7a0b\u4e2d\u6700\u8017\u65f6\u4e14\u6311\u6218\u6027\u6700\u5927\u7684\u90e8\u5206\u5176\u5b9e\u662f\u6536\u96c6\u53ef\u9760\u7684\u52a8\u529b\u5b66\u6570\u636e\u548cpKa\u6d4b\u91cf\u3002\u6211\u4e3a\u4e86\u8fd9\u4e2a\u8bfe\u9898\u524d\u540e\u8fdb\u884c\u4e86\u8d85\u8fc7\u4e00\u767e\u6b21\u52a8\u529b\u5b66\u5b9e\u9a8c\uff0c\u6253\u4e86\u8fd1\u5343\u6b21\u6838\u78c1\u8c31\u3002\u8fd9\u4e9b\u5b9e\u9a8c\u5bf9\u5efa\u7acb\u5173\u7cfb\u5e76\u6df1\u5165\u7406\u89e3\u53cd\u5e94\u673a\u7406\u81f3\u5173\u91cd\u8981\u3002\u6b64\u5916\uff0cpKa\u6d4b\u91cf\u4e5f\u975e\u5e38\u56f0\u96be\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u6d4b\u91cf\u9700\u8981\u5728\u6781\u4f4e\u6d53\u5ea6\u4e0b\u8fdb\u884c\uff0c\u5e76\u4e14\u6c34\u5206\u542b\u91cf\u5fc5\u987b\u63a7\u5236\u5728\u6781\u4f4e\u6c34\u5e73\uff0c\u5426\u5219\u4f1a\u5bfc\u81f4\u6d4b\u91cf\u4e0d\u51c6\u786e\u3002\u8fd9\u4e9b\u7e41\u7410\u7684\u5de5\u4f5c\u786e\u5b9e\u8ba9\u4eba\u611f\u5230\u975e\u5e38\u5403\u529b\u3002<\/p>\n
The most time-consuming and overwhelming aspects were gathering reliable kinetic data and pKa measurements. To ensure accurate data, I probably conducted over a hundred kinetic experiments and nearly a thousand NMR runs. These experiments were crucial for establishing relationships and understanding the reaction mechanisms. Additionally, pKa measurements for a library of compounds were challenging due to the need for measurements at very low concentrations and maintaining an exceptionally low level of water\/oxygen content to avoid inaccuracies. These tasks were indeed quite laborious and mentally demanding.<\/p>\n
Q4. <\/strong>\u5c06\u6765\u60f3\u7ee7\u7eed\u7814\u7a76\u5316\u5b66\u7684\u54ea\u4e2a\u65b9\u5411\u5462\uff1f<\/strong><\/h4>\n
\u6211\u6700\u8fd1\u521a\u521a\u6bd5\u4e1a\uff0c\u5e76\u4e14\u8fdb\u5165\u4e86\u4e00\u5bb6\u6d82\u6599\u516c\u53f8\u5de5\u4f5c\u3002\u672a\u6765\uff0c\u6211\u7684\u7814\u7a76\u5c06\u4e3b\u8981\u96c6\u4e2d\u5728\u5f00\u53d1\u9ad8\u6027\u80fd\u4e14\u73af\u4fdd\u7684\u6d82\u6599\u4e0a\u3002\u6211\u5e0c\u671b\u901a\u8fc7\u7814\u7a76\u548c\u5f00\u53d1\u65b0\u7684\u6d82\u6599\u914d\u65b9\u6765\u63d0\u9ad8\u4ea7\u54c1\u7684\u6027\u80fd\uff0c\u540c\u65f6\u51cf\u5c11\u5bf9\u73af\u5883\u7684\u5f71\u54cd\u3002<\/p>\n
I recently graduated and have started a position at a coatings company. In the future, my research will focus on developing high-performance and eco-friendly coatings. I aim to improve product performance while reducing environmental impact through the development of new coating formulations.<\/p>\n
Q5. <\/strong>\u6700\u540e\uff0c\u6709\u4ec0\u4e48\u60f3\u5bf9\u5404\u4f4d\u8bfb\u8005\u8bf4\u7684\u5417\uff1f<\/strong><\/h4>\n
\u6211\u5e0c\u671b\u6211\u4eec\u7684\u7814\u7a76\u80fd\u591f\u6fc0\u53d1\u66f4\u591a\u7684\u79d1\u7814\u4eba\u5458\u5728\u50ac\u5316\u5242\u8bbe\u8ba1\u548c\u529f\u80fd\u5316\u5b66\u65b9\u9762\u7684\u63a2\u7d22\u3002\u79d1\u5b66\u7814\u7a76\u662f\u4e00\u9879\u56e2\u961f\u5408\u4f5c\u7684\u5de5\u4f5c\uff0c\u6211\u8981\u7279\u522b\u611f\u8c22\u6211\u7684\u56e2\u961f\u6210\u5458,\u5c24\u5176\u662fKai Hin Lui\u548cRachele Zunino\u7684\u9f0e\u529b\u76f8\u52a9\u3002\u5e0c\u671b\u5927\u5bb6\u80fd\u7ee7\u7eed\u5173\u6ce8\u548c\u652f\u6301\u6211\u4eec\u7684\u7814\u7a76\u6210\u679c\u3002\u4e5f\u795d\u613f\u5927\u5bb6\u79d1\u7814\u987a\u5229\uff0c\u591a\u53d1\u8bba\u6587\u3002<\/p>\n
I hope our research inspires more scientists to explore catalyst design and functional chemistry. Scientific research is a collaborative effort, and I am especially grateful to my team members and funding agencies for their support. I look forward to continued attention and support for our research results.<\/p>\n
\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u7b80\u4ecb<\/strong><\/h4>\n
<\/p>\n
\u6559\u80b2\u80cc\u666f\uff1a<\/strong><\/h4>\n
\n
2014- 2018 Carleton College \u5316\u5b66\u5b66\u58eb\u00a0(advisor: Matthew Whited)<\/li>\n

2019-2024 Stanford University \u5316\u5b66\u535a\u58eb (advisor: Robert Waymouth)<\/li>\n<\/ul>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.<\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\uff1a\u77f3\u6cb9\u919a \u672c\u671f\u70ed\u70b9\u7814\u7a76\uff0c\u6211\u4eec\u9080\u8bf7\u5230\u4e86\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\uff0c\u6765\u81ea\u52a0\u65af\u5766\u798f\u5927\u5b66\u7684\u5f20\u5609\u535a\u58eb\u4e3a\u6211\u4eec\u5206\u4eab\u3002 2024\u5e748\u67085\u65e5\uff0cJ. Am. Chem. Soc.\u5728\u7ebf\u53d1\u8868\u4e86\u6765\u81ea\u65af\u5766\u798f\u5927\u5b66\u7684Robert M. Waymouth\u6559\u6388\u56e2\u961f\u9898\u4e3a\u300cHighly Selective\u00a0O-Phenylene Bisurea Catalysts for ROP: Stabilization of Oxyanion Transition State by a Semiflexible Hydrogen Bond Pocket\u300d\u7684\u7814\u7a76\u8bba\u6587\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684O-Phenylene Bisurea (OPBU)\u50ac\u5316\u5242\uff0c\u7528\u4e8e\u73af\u72b6\u5f00\u94fe\u805a\u5408\uff08ROP\uff09\u3002\u8fd9\u79cd\u50ac\u5316\u5242\u4e0d\u4ec5\u53cd\u5e94\u8fc5\u901f\u3001\u53ef\u8c03\u6027\u5f3a\uff0c\u800c\u4e14\u9009\u62e9\u6027\u4f18\u5f02\uff0c\u6bd4\u4f20\u7edf\u50ac\u5316\u5242\uff08\u5982\u786b\u8132\u3001\u5c3f\u7d20\u548cTBD\uff09\u9ad8\u51fa8\u5230120\u500d\u3002OPBU\u50ac\u5316\u5242\u80fd\u5728\u51e0\u79d2\u5230\u51e0\u5206\u949f\u5185\u5b9e\u73b0\u8d85\u8fc795%\u7684\u9ad8\u8f6c\u5316\u7387\uff0c\u4ea7\u751f\u5206\u5b50\u91cf\u7cbe\u51c6\u4e14\u5206\u6563\u5ea6\u6781\u4f4e\u7684\u805a\u5408\u7269\u3002 \u201cHighly Selective\u00a0O-Phenylene Bisurea Catalysts for ROP: Stabilization of Oxyanion Transition State by a Semiflexible Hydrogen Bond Pocket Jia Zhang, Kai Hin Lui, Rachele Zunino, Yuan Jia, Romain Morodo, Niklas Warlin, James L. Hedrick, Giovanni Talarico, Robert M. Waymouth* J. Am. Chem. Soc.\u00a02024, ASAP, doi: 10.1021\/jacs.4c04740\u201d Q1. \u8bf7\u5bf9\u201cHighly Selective\u00a0O-Phenylene Bisurea Catalysts for ROP: Stabilization of Oxyanion Transition State by a Semiflexible Hydrogen Bond Pocket\u201d\u4f5c\u4e00\u4e2a\u7b80\u5355\u4ecb\u7ecd\u3002 \u6211\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7684O-Phenylene Bisurea (OPBU)\u50ac\u5316\u5242\uff0c\u7528\u4e8e\u73af\u72b6\u5f00\u94fe\u805a\u5408\uff08ROP\uff09\u3002\u8fd9\u79cd\u50ac\u5316\u5242\u4e0d\u4ec5\u53cd\u5e94\u8fc5\u901f\u3001\u53ef\u8c03\u6027\u5f3a\uff0c\u800c\u4e14\u9009\u62e9\u6027\u4f18\u5f02\uff0c\u6bd4\u4f20\u7edf\u50ac\u5316\u5242\uff08\u5982\u786b\u8132\u3001\u5c3f\u7d20\u548cTBD\uff09\u9ad8\u51fa8\u5230120\u500d\u3002OPBU\u50ac\u5316\u5242\u80fd\u5728\u51e0\u79d2\u5230\u51e0\u5206\u949f\u5185\u5b9e\u73b0\u8d85\u8fc795%\u7684\u9ad8\u8f6c\u5316\u7387\uff0c\u4ea7\u751f\u5206\u5b50\u91cf\u7cbe\u51c6\u4e14\u5206\u6563\u5ea6\u6781\u4f4e\u7684\u805a\u5408\u7269\u3002\u5bc6\u5ea6\u6cdb\u51fd\u7406\u8bba\uff08DFT\uff09\u8ba1\u7b97\u663e\u793a\uff0c\u50ac\u5316\u5242\u901a\u8fc7\u7c7b\u4f3c\u4e8e\u9176\u50ac\u5316\u4e2d\u7684\u201c\u6c27\u8d1f\u79bb\u5b50\u5b54\u6d1e\u201d\u7684\u6c22\u952e\u53e3\u888b\u7a33\u5b9a\u6c27\u8d1f\u79bb\u5b50\u8fc7\u6e21\u6001\u3002\u8fd9\u4e9b\u65b0\u578b\u50ac\u5316\u5242\u5728\u6709\u673a\u50ac\u5316\u9886\u57df\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\uff0c\u5176\u4f18\u8d8a\u7684\u6027\u80fd\u548c\u53ef\u8c03\u6027\u4e3a\u63a7\u5236\u805a\u5408\u7269\u5408\u6210\u5e26\u6765\u4e86\u65b0\u7684\u53ef\u80fd\u6027\u3002 In this study, we introduced a new type of O-Phenylene Bisurea (OPBU) catalyst for ring-opening polymerization (ROP). 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\u4f5c\u8005\uff1a\u6749\u6749<\/p>\n
\u5bfc\u8bfb\uff1a<\/h4>\n
\u73ab\u7470\uff08rose\uff09\u8c61\u5f81\u7740\u7f8e\u4e3d\u548c\u7231\u60c5\uff0c\u4e0d\u4ec5\u7ed9\u4e86\u4eba\u4eec\u89c6\u89c9\u7684\u4eab\u53d7\uff0c\u800c\u4e14\u4e5f\u7ed9\u4e86\u4eba\u4eec\u55c5\u89c9\u7684\u6109\u60a6\u3002\u73ab\u7470\u82b1\u4e3b\u8981\u5316\u5b66\u6210\u5206\u5305\u62ec\u6325\u53d1\u6cb9\u3001\u9ec4\u916e\u7c7b\u3001\u591a\u915a\u3001\u8272\u7d20\u7c7b\u7b49\u591a\u79cd\u5316\u5b66\u6210\u5206\uff0c\u5177\u6709\u8f83\u5f3a\u6297\u6c27\u5316\u3001\u6297\u80bf\u7624\u3001\u6297\u83cc\u3001\u6297\u75c5\u6bd2\u7b49\u751f\u7406\u6d3b\u6027\u3002\u540c\u65f6\uff0c\u7d20\u6709\u6db2\u4f53\u9ec4\u91d1\u4e4b\u79f0\u7684\u73ab\u7470\u7cbe\u6cb9\uff08rose essential oil\uff09\uff0c\u5177\u6709\u6cbb\u7597\u6291\u90c1\u548c\u7126\u8651\u7b49\u529f\u80fd\u3002\u5728\u672c\u6587\uff0c\u5c0f\u7f16\u5c06\u4ece\u5316\u5b66\u89d2\u5ea6\u5bf9\u73ab\u7470\u82b1\u4e2d\u7684\u6709\u5173\u95ee\u9898\u8fdb\u884c\u89e3\u91ca\uff0c\u5982\u73ab\u7470\u82b1\u4e3a\u4ec0\u4e48\u4f1a\u6709\u4e0d\u540c\u7684\u989c\u8272\uff1f\u9001\u4eba\u73ab\u7470\u624b\u4e3a\u4ec0\u4e48\u4f1a\u6709\u4f59\u9999\uff1f\u73ab\u7470\u7cbe\u6cb9\u662f\u4ec0\u4e48\uff1f<\/p>\n
\u6b63\u6587\uff1a<\/h4>\n
\u4e00\u3001\u73ab\u7470\u82b1\u7684\u4ecb\u7ecd<\/strong><\/p>\n
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\u56fe1 \u9ec4\u73ab\u7470\u7684\u56fe\u7247<\/p>\n
\u4e8c\u3001\u73ab\u7470\u82b1\u7684\u5316\u5b66\u6210\u5206<\/strong><\/p>\n
\u73ab\u7470\u82b1\u7684\u6210\u5206\u6bd4\u8f83\u590d\u6742\uff0c\u4e3b\u8981\u542b\u6709\u6325\u53d1\u6cb9\u3001\u9ec4\u916e\u7c7b\u3001\u591a\u915a\u3001\u8272\u7d20\u7c7b\u7b49\u591a\u79cd\u5316\u5b66\u6210\u5206^{[1]<\/sup>\u3002<\/p>\n}

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\u6325\u53d1\u6cb9<\/strong><\/li>\n<\/ol>\n
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\u56fe2 \u73ab\u7470\u4e2d\u7684\u90e8\u5206\u6325\u53d1\u6027\u7269\u8d28<\/p>\n

\n
\u9ec4\u916e\u7c7b<\/strong><\/li>\n<\/ol>\n
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\n
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\n
\u8272\u7d20\u7c7b<\/strong><\/li>\n<\/ol>\n
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\u56fe4 \u82b1\u9752\u7d20\u7684\u5206\u5b50\u7ed3\u6784<\/p>\n

\n
\u591a\u7cd6\u7c7b<\/strong><\/li>\n<\/ol>\n
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\u4e09\u3001\u73ab\u7470\u82b1\u7684\u989c\u8272<\/strong><\/p>\n
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\u56fe7 \u73ab\u7470\u919a\u7684\u5206\u5b50\u7ed3\u6784<\/p>\n
\u4e94\u3001\u73ab\u7470\u7cbe\u6cb9\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n
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\u56fe8 \u73ab\u7470\u7cbe\u6cb9\u7684\u56fe\u7247<\/p>\n
\u516d\u3001\u690d\u7269\u82b1\u8bed\u5bd3\u610f<\/strong><\/p>\n
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\u56fe9 \u73ab\u7470\u82b1\u8bed<\/p>\n
\u603b\u7ed3\uff1a<\/h4>\n
\u73ab\u7470\u82b1\u662f\u6211\u56fd\u5341\u5927\u4f20\u7edf\u540d\u82b1\u4e4b\u4e00\u3002\u73ab\u7470\u82b1\u662f\u96c6\u836f\u7528\u3001\u98df\u7528\u3001\u5316\u5de5\u3001\u7f8e\u5bb9\u3001\u89c2\u8d4f\u4e3a\u4e00\u4f53\u7684\u540d\u8d35\u4e2d\u836f\u6750\u3002\u73ab\u7470\u7684\u989c\u8272\u6765\u81ea\u82b1\u74e3\u4e2d\u7684\u8272\u7d20\uff0c\u8fd9\u4e9b\u8272\u7d20\u4e3b\u8981\u662f\u82b1\u9752\u7d20\u548c\u7c7b\u80e1\u841d\u535c\u7d20\u3002\u73ab\u7470\u82b1\u4e2d\u9999\u5473\u4e3b\u8981\u662f\u7531\u4e8e\u6325\u53d1\u6027\u7684\u7269\u8d28\uff0c\u5982\u9999\u8305\u9187\u3001\u9999\u53f6\u9187\u3001\u82ef\u4e59\u9187\u3001\u6708\u6842\u70ef\u548c\u03b1<\/em>-\u848e\u70ef\u7b49\u9187\u7c7b\u3001\u919a\u7c7b\u3001\u916f\u7c7b\u4ee5\u53ca\u5404\u79cd\u70f7\u70c3\u7c7b\u5316\u5408\u7269\u3002\u73b0\u4ee3\u591a\u7528\u5b83\u6765\u63d0\u70bc\u7d20\u6709\u6db2\u4f53\u9ec4\u91d1\u4e4b\u79f0\u7684\u73ab\u7470\u7cbe\u6cb9\uff0c\u751f\u4ea7\u5177\u6709\u9ad8\u9644\u52a0\u503c\u7684\u7f8e\u5bb9\u4fdd\u5065\u7cfb\u5217\u4ea7\u54c1\u3002<\/p>\n
\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n
\n
[1] M. H. Boskabady, M. N. Shafei, Z. Saberi, S. Amini,Iran. J. Basic Med Sci.<\/em>2011<\/strong>,14<\/em>, 295. PMCID:

PMC3586833<\/a>.<\/li>\n
[2] \u9b4f\u4e3d\u7434, \u79cd\u57f9\u82b3, \u5305\u65b0\u5149. \u4e0d\u540c\u82b1\u8272\u73ab\u7470\u7c7b\u9ec4\u916e\u6210\u5206\u53ca\u5176\u4e0e\u82b1\u8272\u5173\u7cfb[J]. \u5317\u65b9\u56ed\u827a,2023<\/strong>,09<\/em>, 37. DOI:
10.11937\/bfyy.20223855<\/a>.<\/li>\n
[3] \u5b89\u6bd4\u82b3, \u9648\u521b\u4e1a, \u4e54\u6842\u82b3, \u738b\u9732\u98de, \u9676\u6c38\u971e. \u73ab\u7470\u7cbe\u6cb9\u7684\u63d0\u53d6\u53ca\u5e94\u7528\u7814\u7a76\u8fdb\u5c55[J]. \u5b89\u5fbd\u519c\u4e1a\u79d1\u5b66,2024<\/strong>,52<\/em>, 6. DOI:
10.3969\/j.issn.0517-6611.2024.10.002.<\/a><\/li>\n<\/ul>\n
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\u53c2\u8003\u6587\u732e\uff1a [1] M. H. Boskabady, M. N. Shafei, Z. Saberi, S. Amini, Iran. J. Basic Med Sci. 2011, 14, 295. PMCID: PMC3586833. [2] \u9b4f\u4e3d\u7434, \u79cd\u57f9\u82b3, \u5305\u65b0\u5149. \u4e0d\u540c\u82b1\u8272\u73ab\u7470\u7c7b\u9ec4\u916e\u6210\u5206\u53ca\u5176\u4e0e\u82b1\u8272\u5173\u7cfb[J]. \u5317\u65b9\u56ed\u827a, 2023, 09, 37. DOI: 10.11937\/bfyy.20223855. [3] \u5b89\u6bd4\u82b3, \u9648\u521b\u4e1a, \u4e54\u6842\u82b3, \u738b\u9732\u98de, \u9676\u6c38\u971e. \u73ab\u7470\u7cbe\u6cb9\u7684\u63d0\u53d6\u53ca\u5e94\u7528\u7814\u7a76\u8fdb\u5c55[J]. \u5b89\u5fbd\u519c\u4e1a\u79d1\u5b66, 2024, 52, 6. DOI: 10.3969\/j.issn.0517-6611.2024.10.002. \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d.","protected":false},"author":26,"featured_media":50896,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1274],"tags":[4407,4408,4406,964],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2024\/08\/image001-10.jpg","jetpack_shortlink":"https:\/\/wp.me\/s96op1-50885","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50885"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=50885"}],"version-history":[{"count":3,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50885\/revisions"}],"predecessor-version":[{"id":50901,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/50885\/revisions\/50901"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/50896"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=50885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=50885"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=50885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}]

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\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n
\n
[1] S. W. M. Crossley, C. Obradors, R. M. Martinez, R. A. Shenvi,Chem. Rev. <\/em>2016<\/strong>,116<\/em>, 8912. doi:

\u5168\u5408\u6210\u548c\u521b\u836f\u5316\u5b66\u7684\u76f8\u4f3c\u6027<\/h4>\n

\u5168\u5408\u6210\u548c\u521b\u836f\u7684\u7814\u7a76\u6d41\u7a0b\u5bf9\u6bd4<\/h4>\n
\u7b14\u8005\u5217\u51fa\u4e86\u5168\u5408\u6210\u548c\u521b\u836f\u5404\u81ea\u7684\u7814\u7a76\u6d41\u7a0b\u8868(\u89c1\u4e0b\uff0c\u8868\u683c\u6839\u636e

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n
\n
[1] M. H. Boskabady, M. N. Shafei, Z. Saberi, S. Amini,Iran. J. Basic Med Sci.<\/em>2011<\/strong>,14<\/em>, 295. PMCID:

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n \n [1] S. W. M. Crossley, C. Obradors, R. M. Martinez, R. A. Shenvi,Chem. Rev. <\/em>2016<\/strong>,116<\/em>, 8912. doi:

\u5168\u5408\u6210\u548c\u521b\u836f\u5316\u5b66\u7684\u76f8\u4f3c\u6027<\/h4>\n

\u5168\u5408\u6210\u548c\u521b\u836f\u7684\u7814\u7a76\u6d41\u7a0b\u5bf9\u6bd4<\/h4>\n\u7b14\u8005\u5217\u51fa\u4e86\u5168\u5408\u6210\u548c\u521b\u836f\u5404\u81ea\u7684\u7814\u7a76\u6d41\u7a0b\u8868(\u89c1\u4e0b\uff0c\u8868\u683c\u6839\u636e

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n \n [1] M. H. Boskabady, M. N. Shafei, Z. Saberi, S. Amini,Iran. J. Basic Med Sci.<\/em>2011<\/strong>,14<\/em>, 295. PMCID:

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n
\n
[1] S. W. M. Crossley, C. Obradors, R. M. Martinez, R. A. Shenvi,Chem. Rev. <\/em>2016<\/strong>,116<\/em>, 8912. doi:

\u5168\u5408\u6210\u548c\u521b\u836f\u7684\u7814\u7a76\u6d41\u7a0b\u5bf9\u6bd4<\/h4>\n
\u7b14\u8005\u5217\u51fa\u4e86\u5168\u5408\u6210\u548c\u521b\u836f\u5404\u81ea\u7684\u7814\u7a76\u6d41\u7a0b\u8868(\u89c1\u4e0b\uff0c\u8868\u683c\u6839\u636e

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n
\n
[1] M. H. Boskabady, M. N. Shafei, Z. Saberi, S. Amini,Iran. J. Basic Med Sci.<\/em>2011<\/strong>,14<\/em>, 295. PMCID: